Erythrocyte Ankyrin Products
(Ankyrin 1, Erythrocytic (ANK1))
Categories
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008].
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Featured Erythrocyte Ankyrin Categories
Erythrocyte Ankyrin Antibodies
High quality antibodies with extensive validation data.
Erythrocyte Ankyrin ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended Erythrocyte Ankyrin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN2485521
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN203434
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN2485534
Quantity
100 μg
Datasheet
Datasheet
Recommended Erythrocyte Ankyrin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964879
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1121977
Quantity
96 tests
Datasheet
Datasheet
Recommended Erythrocyte Ankyrin Proteins
Latest Publications for our Erythrocyte Ankyrin products
: "ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status." in: Cancer letters, Vol. 410, pp. 191-200, (2017) (PubMed).: "The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration." in: Cell death & disease, Vol. 7, pp. e2184, (2016) (PubMed).
: "Upregulated expression of cardiac ankyrin repeat protein in human failing hearts due to arrhythmogenic right ventricular cardiomyopathy." in: European journal of heart failure, Vol. 11, Issue 6, pp. 559-66, (2009) (PubMed).
: "Functional links between membrane transport and the spectrin cytoskeleton." in: The Journal of membrane biology, Vol. 211, Issue 3, pp. 151-61, (2006) (PubMed).
Synonyms and alternative names related to Erythrocyte Ankyrin
ankyrin 1 (ANK1), ankyrin 1, erythrocytic a (ank1a), ankyrin 1 (ank1), ankyrin 1 L homeolog (ank1.L), ankyrin 1, erythrocytic (ANK1), ankyrin 1 (Ank1), ankyrin 1, erythroid (Ank1), ank, ANK, Ank-1, ANK1, CHANK1, nb, pale, sph1, SPH1, sph2, SPH2, wu:fa09h06, zgc:101835Protein level used designations for Erythrocyte Ankyrin
- ankyrin 1, erythrocytic
- erythroid ankyrin
- ankyrin-1-like
- ANK-1
- ankyrin-1
- ankyrin-R
- erythrocyte ankyrin
- ankyrin 1, erythroid
- normoblastic anemia
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