ERCC2 Products
(Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
Categories
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
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Featured ERCC2 Categories
ERCC2 Antibodies
High quality antibodies with extensive validation data.
ERCC2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ERCC2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, ICC, IHC (p)
Validations
- (4)
Cat. No.
ABIN2856090
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7171956
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN515384
Quantity
100 μg
Datasheet
Datasheet
Recommended ERCC2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960582
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5608594
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5660069
Quantity
96 tests
Datasheet
Datasheet
Recommended ERCC2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1353031
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353033
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7418473
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ERCC2 products
: "XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage." in: Nucleic acids research, Vol. 43, Issue 11, pp. 5476-88, (2015) (PubMed).: "Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway." in: Mutation research, Vol. 654, Issue 1, pp. 13-21, (2008) (PubMed).
: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." in: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).
Synonyms and alternative names related to ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit (ERCC2), excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), ERCC excision repair 2, TFIIH core complex helicase subunit (Ercc2), excision repair cross-complementation group 2 (ercc2), Xeroderma pigmentosum D (Xpd), AA407812, AU020867, AW240756, CG9433, COFS2, CXPD, DhR3, DhXPD, Dmel\\CG9433, DmXPD, EM9, Ercc-2, ERCC2, l(2)SH2 2137, l(2)SH2137, MGC89573, TTD, XPD, xpd, XPD/ERCC2, zgc:56365Protein level used designations for ERCC2
- BTF2 p80
- CXPD
- DNA excision repair protein ERCC-2
- DNA repair protein complementing XP-D cells
- TFIIH 80 kDa subunit
- TFIIH basal transcription factor complex 80 kDa subunit
- TFIIH basal transcription factor complex helicase XPD subunit
- TFIIH basal transcription factor complex helicase subunit
- TFIIH p80
- basic transcription factor 2 80 kDa subunit
- xeroderma pigmentosum complementary group D
- xeroderma pigmentosum group D-complementing protein
- excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
- excision repair cross-complementing rodent repair deficiency, complementation group 2 protein
- excision repair cross-complementing rodent repair deficiency, complementation group 2
- excision repair cross-complementing 2
- DNA-repair protein complementing XP-D cells
- excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2
- CG9433-PA
- CG9433-PB
- CG9433-PC
- Xpd-PA
- Xpd-PB
- Xpd-PC
- lethal (2) SH2137
- xeroderma pigmentosum D
- XPD
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