ERBB4 Products
(V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
Categories
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
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Featured ERBB4 Categories
ERBB4 Antibodies
High quality antibodies with extensive validation data.
ERBB4 ELISA Kits
Reliable ELISA kits for a wide range of species.
ERBB4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ERBB4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (7)
Cat. No.
ABIN7440776
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
Cat. No.
ABIN6262216
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
Cat. No.
ABIN6256632
Quantity
100 μL
Datasheet
Datasheet
Recommended ERBB4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971099
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971098
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955635
Quantity
96 tests
Datasheet
Datasheet
Recommended ERBB4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274805
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274798
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274806
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ERBB4 products
: "Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling." in: Biochemical and biophysical research communications, Vol. 511, Issue 4, pp. 765-771, (2019) (PubMed).: "Molecular Correlates of In Vitro Responses to Dacomitinib and Afatinib in Bladder Cancer." in: Bladder cancer (Amsterdam, Netherlands), Vol. 4, Issue 1, pp. 77-90, (2018) (PubMed).
: "ERBB4 Expression in Ovarian Serous Carcinoma Resistant to Platinum-Based Therapy." in: Cancer control : journal of the Moffitt Cancer Center, Vol. 24, Issue 1, pp. 89-95, (2017) (PubMed).
: "Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation." in: Translational psychiatry, Vol. 7, Issue 3, pp. e1052, (2017) (PubMed).
: "Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase ..." in: International journal of oncology, Vol. 49, Issue 5, pp. 1825-1838, (2017) (PubMed).
: "Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma." in: Oncology letters, Vol. 14, Issue 5, pp. 5934-5946, (2017) (PubMed).
: "Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer." in: Oncogenesis, Vol. 5, pp. e187, (2016) (PubMed).
: "Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 4, pp. 648-55, (2015) (PubMed).
: "A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation." in: Oncogene, Vol. 34, Issue 17, pp. 2215-26, (2015) (PubMed).
: "Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R." in: PLoS ONE, Vol. 9, Issue 1, pp. e84417, (2014) (PubMed).
Synonyms and alternative names related to ERBB4
erb-b2 receptor tyrosine kinase 4 (ERBB4), erb-b2 receptor tyrosine kinase 4a (erbb4a), v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), erb-b2 receptor tyrosine kinase 4 (erbb4), erb-b2 receptor tyrosine kinase 4 L homeolog (erbb4.L), receptor tyrosine-protein kinase ErbB-4 (Tsp_13582), erb-b2 receptor tyrosine kinase 4 (Erbb4), c-erbB-4, erbb4, Her4, HER4, p180erbB4, si:ch211-227n20.1Protein level used designations for ERBB4
- v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
- erbb4c
- receptor tyrosine-protein kinase erbB-4
- v-erb-a erythroblastic leukemia viral oncogene homolog 4
- receptor tyrosine-protein kinase erbB-4-like
- receptor tyrosine kinase ErbB4
- receptor tyrosine-protein kinase ErbB-4
- ovarian receptor tyrosine kinase erbB4 precusor
- receptor tyrosine kinase
- avian erythroblastosis oncogene B 4
- proto-oncogene-like protein c-ErbB-4
- c-erbB-4
- avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
- tyrosine kinase-type cell surface receptor HER4
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