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ERBB3 Proteins

(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

recommended

ERBB3 Protein (AA 20-643) (His-Avi Tag) (ABIN7274801)

ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

ERBB3 Protein (AA 20-643) (Fc Tag) (ABIN7274797)

ERBB3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

ERBB3 Protein (AA 20-641) (His tag) (ABIN7274795)

ERBB3 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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ERBB3 Proteins by Origin

Find ERBB3 Proteins for a variety of species such as anti-Human ERBB3, anti-Mouse ERBB3, anti-Cynomolgus ERBB3. The species listed below are among those available. Click on a link to go to the corresponding products.

ERBB3 Proteins by Source

Here you will find ERBB3 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ERBB3 Proteins by Protein Type

Here you can find ERBB3 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

ERBB3 Proteins by Application

Find ERBB3 Proteins validated for a specific application such as WB, AbP, ELISA, SDS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ERBB3 Proteins by Biological Activity

Find ERBB3 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular ERBB3 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

ERBB3 Protein (AA 20-643) (His-Avi Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274801

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 20-643) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274797

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 20-641) (His tag)

Reactivity Cynomolgus, Rhesus Monkey

Source HEK-293 Cells

Validations

Cat. No. ABIN7274795

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 20-643) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN6961140

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (His-Avi Tag,Biotin)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7274802

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 544-643) (Fc Tag)

Reactivity Human

Source Mammalian Cells

Validations

Cat. No. ABIN7538507

Quantity 50 μg

Datasheet Datasheet

ERBB3 Protein (AA 544-643) (mFc Tag)

Reactivity Human

Source Mammalian Cells

Validations

Cat. No. ABIN7538508

Quantity 50 μg

Datasheet Datasheet

ERBB3 Protein (AA 1005-1230) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124803

Quantity 50 μg

Datasheet Datasheet

ERBB3 Protein (AA 1-130) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353019

Quantity 10 μg

Datasheet Datasheet

ERBB3 Protein (AA 21-331) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353017

Quantity 10 μg

Datasheet Datasheet

ERBB3 Protein (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7320073

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (Biotin,His-Avi Tag)

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN7319879

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 20-643) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN6938840

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (AA 20-641) (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7013406

Quantity 100 μg

Datasheet Datasheet

ERBB3 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2720372

Quantity 20 μg

Datasheet Datasheet

Latest Publications for our ERBB3 Proteins

DAgostino, Gentile, Ponziani, Di Vittorio, Dituri, Giannelli, Rossi, Marzullo, Giansanti, De Laurenzi, Iacobelli, Ippoliti, Capone, Sala: "EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer." in: Oncology reports, Vol. 45, Issue 2, pp. 776-785, (2021) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Capone, Lamolinara, DAgostino, Rossi, De Laurenzi, Iezzi, Iacobelli, Sala: "EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 277, pp. 48-56, (2019) (PubMed).

Sala, Rapposelli, Ghasemi, Piccolo, Traini, Capone, Rossi, Pelliccia, Di Risio, DEgidio, Tinari, Muraro, Iacobelli: "EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo." in: Translational oncology, Vol. 6, Issue 6, pp. 676-84, (2014) (PubMed).

Nilvebrant, Astrand, Löfblom, Hober: "Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3." in: Cellular and molecular life sciences : CMLS, Vol. 70, Issue 20, pp. 3973-85, (2013) (PubMed).

Aliases for ERBB3 Proteins

erb-b2 receptor tyrosine kinase 3 (ERBB3) Proteins
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) Proteins
erb-b2 receptor tyrosine kinase 3 (Erbb3) Proteins
c-erbB-3 Proteins
c-erbB3 Proteins
C76256 Proteins
ErbB-3 Proteins
Erbb-3 Proteins
ERBB3 Proteins
erbB3-S Proteins
Erbb3r Proteins
HER3 Proteins
Her3 Proteins
LCCS2 Proteins
MDA-BF-1 Proteins
nuc-ErbB3 Proteins
p45-sErbB3 Proteins
p85-sErbB3 Proteins
p180-ErbB3 Proteins

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ERBB3 Proteins by Origin

ERBB3 Proteins by Source

ERBB3 Proteins by Protein Type

ERBB3 Proteins by Application

ERBB3 Proteins by Biological Activity

Popular ERBB3 Proteins

Latest Publications for our ERBB3 Proteins

Aliases for ERBB3 Proteins

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