ERBB3 Products
(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
Categories
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
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Featured ERBB3 Categories
ERBB3 Antibodies
High quality antibodies with extensive validation data.
ERBB3 ELISA Kits
Reliable ELISA kits for a wide range of species.
ERBB3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ERBB3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7440773
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), FACS
Validations
- (4)
- (5)
Cat. No.
ABIN391949
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN747113
Quantity
100 μL
Datasheet
Datasheet
Recommended ERBB3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN1981720
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959065
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959066
Quantity
96 tests
Datasheet
Datasheet
Recommended ERBB3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7274801
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274797
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus, Rhesus Monkey
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274795
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ERBB3 products
: "EV20‑sss‑vc/MMAF, an HER‑3 targeting antibody‑drug conjugate displays antitumor activity in liver cancer." in: Oncology reports, Vol. 45, Issue 2, pp. 776-785, (2021) (PubMed).: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 277, pp. 48-56, (2019) (PubMed).
: "Soluble HER3 predicts survival in bladder cancer patients." in: Oncology letters, Vol. 15, Issue 2, pp. 1783-1788, (2018) (PubMed).
: "Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients." in: BMC cancer, Vol. 17, Issue 1, pp. 841, (2018) (PubMed).
: "Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141381, (2015) (PubMed).
: "A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations." in: Proteomics, Vol. 15, Issue 2-3, pp. 318-26, (2015) (PubMed).
: "HER2 missense mutations have distinct effects on oncogenic signaling and migration. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 45, pp. E6205-14, (2015) (PubMed).
: "A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation." in: Oncogene, Vol. 34, Issue 17, pp. 2215-26, (2015) (PubMed).
: "A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism." in: The Journal of biological chemistry, (2015) (PubMed).
Synonyms and alternative names related to ERBB3
erb-b2 receptor tyrosine kinase 3 (ERBB3), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), erb-b2 receptor tyrosine kinase 3 (Erbb3), c-erbB-3, c-erbB3, C76256, ErbB-3, Erbb-3, ERBB3, erbB3-S, Erbb3r, HER3, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3Protein level used designations for ERBB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
- receptor tyrosine kinase ErbB3
- receptor tyrosine-protein kinase erbB-3-like
- avian erythroblastosis oncogene B 3 receptor
- c-erbB-3
- glial growth factor receptor
- receptor tyrosine kinase
- avian erythroblastosis oncogene B 3
- c-erbB3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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