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This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008].
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EPI Antibodies
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EPI ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended EPI Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Various Species
Application
ELISA, CLIA, ICC, IHC (fro)
Validations
Cat. No.
ABIN7438283
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Chemical
Application
ELISA
Validations
Cat. No.
ABIN2614876
Quantity
100 μL
Datasheet
Datasheet
Recommended EPI ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Various Species
Analytical Method
Quantitative Competition ELISA
Validations
- (7)
- (1)
Cat. No.
ABIN6955621
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Various Species
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
Cat. No.
ABIN6966558
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Various Species
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
Cat. No.
ABIN6999414
Quantity
96 tests
Datasheet
Datasheet
Recommended EPI Proteins
Latest Publications for our EPI products
: "RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis." in: Frontiers in endocrinology, Vol. 11, pp. 194, (2020) (PubMed).: "Caffeine supplementation induces higher IL-6 and IL-10 plasma levels in response to a treadmill exercise test." in: Journal of the International Society of Sports Nutrition, Vol. 17, Issue 1, pp. 47, (2020) (PubMed).
: "Experimental Models of Endotheliopathy: Impact of Shock Severity." in: Shock (Augusta, Ga.), Vol. 49, Issue 5, pp. 564-571, (2018) (PubMed).
: "Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation." in: Neuropeptides, Vol. 65, pp. 21-27, (2018) (PubMed).
: "Non-pharmacological interventions during childbirth for pain relief, anxiety, and neuroendocrine stress parameters: A randomized controlled trial." in: International journal of nursing practice, Vol. 24, Issue 3, pp. e12642, (2018) (PubMed).
: "Acute bout of exercise induced prolonged muscle glucose transporter-4 translocation and delayed counter-regulatory hormone response in type 1 diabetes." in: PLoS ONE, Vol. 12, Issue 6, pp. e0178505, (2017) (PubMed).
: "Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria." in: PLoS ONE, Vol. 11, Issue 5, pp. e0154398, (2016) (PubMed).
: "Reduced lipolysis response to adipose afferent reflex involved in impaired activation of adrenoceptor-cAMP-PKA-hormone sensitive lipase pathway in obesity." in: Scientific reports, Vol. 6, pp. 34374, (2016) (PubMed).
: "Study of baicalin on sympathoexcitation induced by myocardial ischemia via P2X3 receptor in superior cervical ganglia." in: Autonomic neuroscience : basic & clinical, Vol. 189, pp. 8-15, (2015) (PubMed).
: "Activation of RAW 264.7 cells by a polysaccharide isolated from Antarctic bacterium Pseudoaltermonas sp. S-5." in: Carbohydrate polymers, Vol. 130, pp. 97-103, (2015) (PubMed).
Synonyms and alternative names related to EPI
tissue factor pathway inhibitor (TFPI), EPI, LACI, TFI, TFPI1Protein level used designations for EPI
- anti-convertin
- extrinsic pathway inhibitor
- tissue factor pathway inhibitor
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