EP400 Products
(E1A Binding Protein P400 (EP400))
Categories
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). Regulates transcriptional activity of ZNF42.
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Featured EP400 Categories
EP400 Antibodies
High quality antibodies with extensive validation data.
Recommended EP400 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN528254
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN528253
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6140195
Quantity
100 μL
Datasheet
Datasheet
Recommended EP400 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352867
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our EP400 products
: "ANP32E is a histone chaperone that removes H2A.Z from chromatin." in: Nature, Vol. 505, Issue 7485, pp. 648-53, (2014) (PubMed).: "Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines." in: Cell reports, Vol. 8, Issue 6, pp. 1808-18, (2014) (PubMed).
: "PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells." in: PLoS ONE, Vol. 7, Issue 4, pp. e34848, (2012) (PubMed).
: "Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP." in: PLoS ONE, Vol. 6, Issue 6, pp. e20718, (2011) (PubMed).
: "Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3752-7, (2010) (PubMed).
: "NCoR1 mediates papillomavirus E8;E2C transcriptional repression." in: Journal of virology, Vol. 84, Issue 9, pp. 4451-60, (2010) (PubMed).
: "The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 31-43, (2010) (PubMed).
: "VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400." in: Nature cell biology, Vol. 10, Issue 3, pp. 361-9, (2008) (PubMed).
Synonyms and alternative names related to EP400
E1A binding protein p400 (EP400), E1A binding protein p400 (Ep400), EP400 N-terminal-like protein (LOC738562), helicase domino (LOC5570719), E1a binding protein P400 (CpipJ_CPIJ007689), E1a binding protein P400 (CpipJ_CPIJ007688), E1a binding protein P400 (CpipJ_CPIJ007686), E1a binding protein P400 (CpipJ_CPIJ008061), 1700020J09Rik, AU023439, CAGH32, mDomino, mKIAA1498, P400, p400, TNRC12Protein level used designations for EP400
- CAG repeat protein 32
- E1A-binding protein p400
- domino homolog
- hDomino
- p400 SWI2/SNF2-related protein
- p400 kDa SWI2/SNF2-related protein
- trinucleotide repeat containing 12
- trinucleotide repeat-containing gene 12 protein
- E1A binding protein p400
- E1a binding protein P400
- e1A-binding protein p400-like
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