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ELANE Proteins

(Elastase, Neutrophil Expressed (ELANE))

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].

recommended

ELANE Protein (AA 168-267) (GST tag) (ABIN1352646)

ELANE Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

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recommended

ELANE Protein (ABIN1048116)

ELANE Origin: Human Recombinant > 95 % (SDS-PAGE)

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recommended

ELANE Protein (AA 30-247) (His tag,GST tag) (ABIN7389194)

ELANE Origin: Human Host: Escherichia coli (E. coli) Recombinant > 97 % SDS, WB, Imm, PC

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ELANE Proteins by Origin

Find ELANE Proteins for a variety of species such as anti-Human ELANE, anti-Dog ELANE, anti-Mouse ELANE. The species listed below are among those available. Click on a link to go to the corresponding products.

ELANE Proteins by Source

Here you will find ELANE Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ELANE Proteins by Protein Type

Here you can find ELANE Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

ELANE Proteins by Application

Find ELANE Proteins validated for a specific application such as SDS, WB, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ELANE Proteins by Biological Activity

Find ELANE Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular ELANE Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

ELANE Protein (AA 168-267) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1352646

Quantity 10 μg

Datasheet Datasheet

ELANE Protein

Reactivity Human

Source

Validations

Cat. No. ABIN1048116

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 30-247) (His tag,GST tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7389194

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 30-247) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7424920

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 31-248) (His tag)

Reactivity Dog

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7389191

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7389200

Quantity 100 μg

Datasheet Datasheet

ELANE Protein

Reactivity Human

Source Human

Validations

Cat. No. ABIN3071957

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 29-247) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7389197

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 30-267) (GST tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN5709463

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 30-267) (His tag)

Reactivity Human

Source Yeast

Validations

Cat. No. ABIN5713426

Quantity 100 μg

Datasheet Datasheet

ELANE Protein (AA 30-247, ELA2) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN6238750

Quantity 50 μg

Datasheet Datasheet

ELANE Protein

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN6122495

Quantity 100 μg

Datasheet Datasheet

ELANE Protein

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN6122499

Quantity 100 μg

Datasheet Datasheet

ELANE Protein

Reactivity Dog

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN6379141

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our ELANE Proteins

Bolatchiev, Baturin, Bazikov, Maltsev, Kunitsina: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).

Luyendyk, Shaw, Green, Maddox, Ganey, Roth: "Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine." in: The Journal of pharmacology and experimental therapeutics, Vol. 314, Issue 3, pp. 1023-31, (2005) (PubMed).

Aliases for ELANE Proteins

elastase, neutrophil expressed (ELANE) Proteins
elastase, neutrophil expressed (Elane) Proteins
proteinase 3 (prtn3) Proteins
ELA2 Proteins
Ela2 Proteins
ela2 Proteins
ELANE Proteins
F430011M15Rik Proteins
GE Proteins
HLE Proteins
HNE Proteins
NE Proteins
PMN-E Proteins
SCN1 Proteins

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ELANE Proteins by Origin

ELANE Proteins by Source

ELANE Proteins by Protein Type

ELANE Proteins by Application

ELANE Proteins by Biological Activity

Popular ELANE Proteins

Latest Publications for our ELANE Proteins

Aliases for ELANE Proteins

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