ELANE Products
(Elastase, Neutrophil Expressed (ELANE))
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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
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Featured ELANE Categories
ELANE Antibodies
High quality antibodies with extensive validation data.
ELANE ELISA Kits
Reliable ELISA kits for a wide range of species.
ELANE Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ELANE Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, FACS
Validations
- (6)
Cat. No.
ABIN5611333
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (7)
Cat. No.
ABIN6140110
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7431269
Quantity
100 μL
Datasheet
Datasheet
Recommended ELANE ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6955518
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955517
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6955519
Quantity
96 tests
Datasheet
Datasheet
Recommended ELANE Proteins
Latest Publications for our ELANE products
: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).: "Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation." in: Cell death & disease, Vol. 10, Issue 9, pp. 678, (2020) (PubMed).
: "Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer." in: Pathology oncology research : POR, Vol. 26, Issue 3, pp. 1781-1785, (2020) (PubMed).
: "MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes." in: Journal of clinical immunology, Vol. 40, Issue 1, pp. 147-157, (2020) (PubMed).
: "Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats." in: Bioscience reports, Vol. 39, Issue 12, (2020) (PubMed).
: "Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 7323986, (2020) (PubMed).
: "Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis." in: Cytokine, Vol. 127, pp. 154987, (2020) (PubMed).
: "Corneal epithelial injury-induced norepinephrine promotes Pseudomonas aeruginosa keratitis." in: Experimental eye research, Vol. 195, pp. 108048, (2020) (PubMed).
: "Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats." in: Behavioural brain research, Vol. 359, pp. 304-311, (2019) (PubMed).
: "Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats." in: Neuroscience, Vol. 381, pp. 46-58, (2019) (PubMed).
Synonyms and alternative names related to ELANE
elastase, neutrophil expressed (ELANE), elastase, neutrophil expressed (Elane), proteinase 3 (prtn3), ELA2, Ela2, ela2, ELANE, F430011M15Rik, GE, HLE, HNE, NE, PMN-E, SCN1Protein level used designations for ELANE
- PMN elastase
- bone marrow serine protease
- elastase 2, neutrophil
- elastase-2
- granulocyte-derived elastase
- human leukocyte elastase
- leukocyte elastase
- medullasin
- neutrophil elastase
- polymorphonuclear elastase
- serine protease
- elastase, neutrophil expressed
- LOW QUALITY PROTEIN: neutrophil elastase
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