EIF3E Products
(Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
Categories
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}.
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Featured EIF3E Categories
EIF3E Antibodies
High quality antibodies with extensive validation data.
EIF3E Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EIF3E Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN2783260
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Zebrafish (Danio rerio)
Application
WB
Validations
- (5)
- (2)
Cat. No.
ABIN1881290
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN561508
Quantity
50 μL
Datasheet
Datasheet
Recommended EIF3E Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352556
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352558
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2720079
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our EIF3E products
: "An oncogenic role of eIF3e/INT6 in human breast cancer." in: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).
: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." in: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).
: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).
: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." in: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).
: "A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences." in: Journal of virology, Vol. 79, Issue 15, pp. 10093-6, (2005) (PubMed).
: "Int6 expression can predict survival in early-stage non-small cell lung cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 9, pp. 3198-204, (2005) (PubMed).
: "Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation." in: Molecular biology of the cell, Vol. 11, Issue 11, pp. 4005-18, (2001) (PubMed).
Synonyms and alternative names related to EIF3E
eukaryotic translation initiation factor 3 subunit E (EIF3E), eukaryotic translation initiation factor 3, subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (eif3e), eukaryotic translation initiation factor 3 subunit E L homeolog (eif3e.L), eukaryotic translation initiation factor 3 subunit 6 (LOC692936), eukaryotic translation initiation factor 3 subunit E S homeolog (eif3e.S), eukaryotic translation initiation factor 3, subunit E, a (eif3ea), Eukaryotic translation initiation factor 3 subunit E (eif-3.E), eukaryotic translation initiation factor 3, subunit E, b (eif3eb), eukaryotic translation initiation factor 3 subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (LOC108348260), eukaryotic translation initiation factor 3 subunit E (int6), 48kDa, eIF3-p46, EIF3-P48, eIF3-p48, eif3-p48, eIF3-S6, eIF3e, EIF3S6, Eif3s6, eif3s6, eif3s6-A, eif3s6-B, eif3s6b, EIF3SE, im:7147439, INT6, Int6, QtsA-18056Protein level used designations for EIF3E
- eIF-3 p48
- eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E
- eukaryotic translation initiation factor 3, subunit 6 (48kD)
- eukaryotic translation initiation factor 3, subunit 6 48kDa
- mammary tumor-associated protein INT6
- murine mammary tumor integration site 6 (oncogene homolog)
- viral integration site protein INT-6 homolog
- MMTV integration site 6
- mammary tumor integration site 6
- mammary tumor-associated protein INT-6
- viral integration site protein INT-6
- eukaryotic translation initiation factor 3, subunit 6
- eukaryotic translation initiation factor 3 subunit E-A
- Eukaryotic translation initiation factor 3 subunit 6-A
- eukaryotic translation initiation factor 3 subunit E-B
- Eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit E
- Eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E-like
- eIF3e-B
- eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit 6b
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