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EIF2S1 Products

(Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

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The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2\; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3\; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].

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Featured EIF2S1 Categories

EIF2S1 Antibodies

High quality antibodies with extensive validation data.

EIF2S1 ELISA Kits

Reliable ELISA kits for a wide range of species.

EIF2S1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended EIF2S1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (2)
  • (13)
Cat. No. ABIN6255389
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (1)
  • (7)
Cat. No. ABIN560711
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog, Human, Monkey, Rat
Application WB, IHC, IHC (p)
Validations
  • (7)
Cat. No. ABIN1497972
Quantity 100 μL
Datasheet Datasheet

Recommended EIF2S1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966606
Quantity 96 tests
Datasheet Datasheet

Recommended EIF2S1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352542
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN667786
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7420222
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our EIF2S1 products

Cai, Zheng, Gu, Wang, Wang, Yang, Zhang, Wang, Fu, Wang: "Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78." in: Cell death & disease, Vol. 9, Issue 6, pp. 636, (2018) (PubMed).

Liu, Shen, Wang, Liu, Zheng, Luo: "EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes." in: Journal of cellular biochemistry, (2018) (PubMed).

Chiu, Yeh, Wang, Huang, Ho, Lin, Wang et al.: "Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an ..." in: Molecular cancer, Vol. 15, Issue 1, pp. 46, (2017) (PubMed).

So, Chen, Wang, Wu, Huang, Lai, Pan, Kang, Huang: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).

Hsu, Simon, Neill, Marcotte, Sayad, Bland, Echeverria, Sun, Kurley, Tyagi, Karlin, Dominguez-Vidaña, Hartman, Renwick, Scorsone, Bernardi, Skinner, Jain, Orellana, Lagisetti, Golding, Jung, Neilson et al.: "The spliceosome is a therapeutic vulnerability in MYC-driven cancer. ..." in: Nature, Vol. 525, Issue 7569, pp. 384-8, (2015) (PubMed).

Weinlich, Hüttelmaier, Schierhorn, Behrens, Ostareck-Lederer, Ostareck: "IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR." in: RNA (New York, N.Y.), Vol. 15, Issue 8, pp. 1528-42, (2009) (PubMed).

Connolly, Braunstein, Formenti, Schneider: "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3955-65, (2006) (PubMed).

Chu, Ferro: "Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 291, Issue 5, pp. L983-92, (2006) (PubMed).

Kubota, Obata, Ota, Sasaki, Ito: "Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20457-60, (2003) (PubMed).

Jacob, Silverman, Cohen, Safer: "Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha." in: The Journal of biological chemistry, Vol. 264, Issue 34, pp. 20372-84, (1990) (PubMed).

Synonyms and alternative names related to EIF2S1

eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), eukaryotic translation initiation factor 2, subunit 1 alpha a (eif2s1a), eukaryotic translation initiation factor 2 subunit alpha (Eif2s1), eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1), eukaryotic translation initiation factor 2 subunit alpha (eif2s1), eukaryotic translation initiation factor 2 alpha subunit (LOC693063), eukaryotic translation initiation factor 2 alpha subunit (CNI00230), eukaryotic translation initiation factor 2 alpha subunit (THAPSDRAFT_105), Eukaryotic translation initiation factor 2 subunit 1 (if2a), eukaryotic translation initiation factor 2 subunit alpha L homeolog (eif2s1.L), eukaryotic translation Initiation Factor 2alpha (eIF-2alpha), 35kDa, 0910001O23Rik, 2410026C18Rik, CG9946, deIF2alpha, Dmel\\CG9946, EIF-2, eIF-2, eIF-2 a, eIF-2 alpha, EIF-2A, EIF-2alpha, eiF-2alpha, EIF2, eIF2 alpha, eIF2-alpha, EIF2A, Eif2a, eif2a, eIF2a, eIF2alpha, Eif2alpha, Eif2s1, eif2s1l, elF2alpha, fb36a08, IF2A_DROME, l(1)14Cf, l(1)19-153, M(1)8e3-10, M(1)14C, M(1)19-153, wu:fb36a08, zgc:56510

Protein level used designations for EIF2S1

  • eIF-2-alpha
  • eukaryotic translation initiation factor 2 subunit 1
  • eukaryotic translation initiation factor 2 subunit alpha
  • eukaryotic translation initiation factor 2, subunit 1 alpha
  • eukaryotic translation initiation factor 2, subunit 1 alpha, like
  • EIF-2A
  • EIF-2alpha
  • eIF-2A
  • eIF-2alpha
  • eukaryotic translation initiation factor 2A
  • eukaryotic translation initiation factor 2 alpha subunit
  • Eukaryotic translation initiation factor 2 subunit 1
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
  • eukaryotic translation initiation factor 2, subunit 1 (alpha )
  • CG9946-PA
  • eIF-2alpha-PA
  • eukaryotic initiation factor 2alpha
  • eukaryotic translation initiation factor 2
  • eukaryotic translation initiation factor 2alpha
  • minute (1) 14C
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