EIF2AK2 Products
(Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
Categories
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Featured EIF2AK2 Categories
EIF2AK2 Antibodies
High quality antibodies with extensive validation data.
EIF2AK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
EIF2AK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EIF2AK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (3)
- (6)
Cat. No.
ABIN519273
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS
Validations
- (7)
Cat. No.
ABIN2682988
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN562440
Quantity
100 μg
Datasheet
Datasheet
Recommended EIF2AK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
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Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966608
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955663
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380684
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended EIF2AK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352502
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508905
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7415554
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our EIF2AK2 products
: "PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation." in: Brain pathology (Zurich, Switzerland), (2020) (PubMed).: "AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18." in: Oncoimmunology, Vol. 5, Issue 6, pp. e1160182, (2016) (PubMed).
: "Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division." in: Journal of cellular physiology, Vol. 229, Issue 8, pp. 1047-60, (2014) (PubMed).
: "Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinoma cells by activating STAT3." in: Oncology letters, Vol. 8, Issue 6, pp. 2762-2768, (2014) (PubMed).
: "PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells." in: Blood, Vol. 121, Issue 17, pp. 3364-74, (2013) (PubMed).
: "PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis." in: Blood cancer journal, Vol. 3, pp. e144, (2013) (PubMed).
: "Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells." in: BMC systems biology, Vol. 7, pp. 9, (2013) (PubMed).
: "Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin." in: PLoS ONE, Vol. 7, Issue 9, pp. e46040, (2012) (PubMed).
: "Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues." in: American journal of physiology. Cell physiology, Vol. 299, Issue 4, pp. C736-49, (2010) (PubMed).
: "Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN ..." in: The Journal of biological chemistry, Vol. 281, Issue 27, pp. 18734-45, (2006) (PubMed).
Synonyms and alternative names related to EIF2AK2
eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), eukaryotic translation initiation factor 2-alpha kinase 2 (eif2ak2), eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2), 2310047A08Rik, 4732414G15Rik, AI467567, AI747578, DKFZp469K1934, EIF2AK1, EIF2AK2, PKR, pkr, Pkr, PRKR, Prkr, TikProtein level used designations for EIF2AK2
- double-stranded RNA-activated protein kinase
- interferon-induced, double-stranded RNA-activated protein kinase
- p68 kinase
- P1/eIF-2A protein kinase
- interferon-inducible RNA-dependent protein kinase
- IFN-stimulated dsRNA-activated eIF2-alpha kinase 2
- double-stranded RNA activated protein kinase
- eukaryotic translation initiation factor 2-alpha kinase 2
- double stranded RNA activated protein kinase
- eIF-2A protein kinase 2
- interferon-inducible elF2alpha kinase
- protein kinase, interferon-inducible double stranded RNA dependent
- tyrosine-protein kinase EIF2AK2
- IFN- type I-induced and dsRNA-activated kinase
- IFN-induced and double-stranded RNA-activated kinase
- T-cell viral integration site
- dsRNA-activated kinase
- eIF-2 alpha
- eukaryotic translation initiation factor 2 alpha kinase 2
- protein kinase RNA-activated
- protein kinase, interferon inducible double stranded RNA dependent
- serine/threonine-protein kinase TIK
- Protein kinase, interferon-inducible double stranded RNA dependent
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