EDG4 Products
(Lysophosphatidic Acid Receptor 2 (LPAR2))
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This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
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Featured EDG4 Categories
EDG4 Antibodies
High quality antibodies with extensive validation data.
EDG4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EDG4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
- (3)
Cat. No.
ABIN390085
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC (p), ICC
Validations
- (3)
Cat. No.
ABIN1910280
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7139908
Quantity
100 μL
Datasheet
Datasheet
Recommended EDG4 Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
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Cat. No.
ABIN1309684
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN1330288
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
Cat. No.
ABIN7538365
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our EDG4 products
: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." in: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).: "LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways." in: PLoS ONE, Vol. 10, Issue 9, pp. e0139094, (2015) (PubMed).
: "LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs." in: Molecular and cellular biochemistry, Vol. 408, Issue 1-2, pp. 147-54, (2015) (PubMed).
: "In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity." in: The Journal of cell biology, Vol. 206, Issue 1, pp. 113-27, (2014) (PubMed).
: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).
: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." in: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).
: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." in: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).
: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." in: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).
: "RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, Issue 10, pp. 1612-20, (2007) (PubMed).
: "Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses." in: BMC genomics, Vol. 7, pp. 210, (2006) (PubMed).
Synonyms and alternative names related to EDG4
lysophosphatidic acid receptor 2 (LPAR2), lysophosphatidic acid receptor 2 S homeolog (lpar2.S), G protein-coupled bile acid receptor 1 (GPBAR1), lysophosphatidic acid receptor 2 (Lpar2), growth hormone releasing hormone receptor (GHRHR), lysophosphatidic acid receptor 2a (lpar2a), EDG-4, EDG4, Edg4, Gpbar1, IPA2, LPA-2, LPA2, lpa2, Pbx4, RGD1561336, zgc:101053Protein level used designations for EDG4
- G protein-coupled receptor
- LPA receptor 2
- LPA receptor EDG4
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
- lysophosphatidic acid receptor EDG4
- lysophosphatidic acid receptor Edg-4
- G-protein coupled bile acid receptor 1
- LPA-2
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4
- GHRF receptor
- GHRH receptor
- GRF receptor
- growth hormone-releasing hormone receptor
- pituitary growth hormone releasing hormone receptor
- pre-B-cell leukemia transcription factor 4
- lysophosphatidic acid receptor 2
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