E2F1 Products
(E2F Transcription Factor 1 (E2F1))
Categories
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].
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Featured E2F1 Categories
E2F1 Antibodies
High quality antibodies with extensive validation data.
E2F1 ELISA Kits
Reliable ELISA kits for a wide range of species.
E2F1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended E2F1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (4)
- (6)
Cat. No.
ABIN969516
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, IF
Validations
- (5)
Cat. No.
ABIN7127462
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, PLA
Validations
- (5)
Cat. No.
ABIN560676
Quantity
100 μg
Datasheet
Datasheet
Recommended E2F1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955489
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380168
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative
Validations
Cat. No.
ABIN773114
Quantity
96 tests
Datasheet
Datasheet
Recommended E2F1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352229
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2719894
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409272
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our E2F1 products
: "Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo." in: International journal of oncology, Vol. 57, Issue 3, pp. 697-706, (2020) (PubMed).: "Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting." in: Scientific reports, Vol. 7, Issue 1, pp. 10237, (2019) (PubMed).
: "The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α." in: Frontiers in oncology, Vol. 9, pp. 654, (2019) (PubMed).
: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, (2018) (PubMed).
: "Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 107, (2018) (PubMed).
: "E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair." in: Oncotarget, Vol. 7, Issue 18, pp. 26275-92, (2018) (PubMed).
: "Dependence of p53-deficient cells on the DHX9 DExH-box helicase." in: Oncotarget, Vol. 8, Issue 19, pp. 30908-30921, (2017) (PubMed).
: "Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24538-24550, (2017) (PubMed).
: "Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease." in: Aging, Vol. 8, Issue 2, pp. 272-90, (2016) (PubMed).
: "GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways." in: International journal of molecular sciences, Vol. 16, Issue 9, pp. 21897-910, (2016) (PubMed).
Synonyms and alternative names related to E2F1
E2F transcription factor 1 (E2f1), E2F transcription factor 1 (E2F1), E2F transcription factor 1 L homeolog (e2f1.L), ATE2FB, CG6376, dE2F, dE2f, dE2F1, dE2f1, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, E2F, e2f, E2F-1, E2F1, E2f1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2FProtein level used designations for E2F1
- CG6376-PA
- CG6376-PB
- CG6376-PC
- CG6376-PD
- E2-promoter binding factor
- E2f-PA
- E2f-PB
- E2f-PC
- E2f-PD
- PBR3
- PRB-binding protein E2F-1
- RBAP-1
- RBBP-3
- retinoblastoma-associated protein 1
- retinoblastoma-binding protein 3
- transcription factor E2F1
- E2F-1 transcription factor
- E2F-1
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