Dynamitin Products
(Dynactin 2 (p50) (DCTN2))
Categories
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012].
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Dynamitin Antibodies
High quality antibodies with extensive validation data.
Dynamitin ELISA Kits
Reliable ELISA kits for a wide range of species.
Dynamitin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Dynamitin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7260303
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (4)
Cat. No.
ABIN523956
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN564596
Quantity
100 μg
Datasheet
Datasheet
Recommended Dynamitin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381385
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882620
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386396
Quantity
96 tests
Datasheet
Datasheet
Recommended Dynamitin Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122716
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351224
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351222
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Dynamitin products
: "Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls." in: Aging cell, Vol. 15, Issue 5, pp. 924-39, (2016) (PubMed).: "Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum." in: Scientific reports, Vol. 5, pp. 8389, (2015) (PubMed).
: "Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5." in: The Biochemical journal, Vol. 463, Issue 3, pp. 339-49, (2014) (PubMed).
: "Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling." in: Oncogene, Vol. 21, Issue 13, pp. 1945-54, (2002) (PubMed).
: "beta III spectrin binds to the Arp1 subunit of dynactin." in: The Journal of biological chemistry, Vol. 276, Issue 39, pp. 36598-605, (2001) (PubMed).
: "ZW10 helps recruit dynactin and dynein to the kinetochore." in: The Journal of cell biology, Vol. 142, Issue 3, pp. 763-74, (1998) (PubMed).
: "Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution." in: The Journal of cell biology, Vol. 139, Issue 2, pp. 469-84, (1997) (PubMed).
: "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis." in: The Journal of cell biology, Vol. 132, Issue 4, pp. 617-33, (1996) (PubMed).
Synonyms and alternative names related to Dynamitin
dynactin subunit 2 (DCTN2), dynactin subunit 2 S homeolog (dctn2.S), Dynactin 2, p50 subunit (DCTN2-p50), dynactin subunit 2 (dctn2), dynactin 2 (Dctn2), dynactin subunit 2 (Dctn2), dynactin 2 (p50) (dctn2), dynactin subunit 2 L homeolog (dctn2.L), 2310042E05Rik, C87049, C130077D06Rik, CG8269, DCTN-50, DCTN2, dctn2, dctn50, DCTN50, dDyn, Dmel\\CG8269, DMN, dmn, dyna, dynamitin, DYNAMITIN, GMP23-48K, l(2)k16109, l(2)k16218, P50, p50, p50/Dmn, p50/dynamitin, rbp50, RBP50, zgc:63867Protein level used designations for Dynamitin
- dynactin 2 (p50)
- dynactin subunit 2
- dynactin subunit 2-B
- dynamitin
- CG8269-PA
- Dmn-PA
- p50-dynamitin
- p50 dynamitin
- p50/Dynamitin
- 50 kDa dynein-associated polypeptide
- dynactin complex 50 kDa subunit
- growth cone membrane protein 23-48K
- 50 kD dynein-associated polypeptide
- dynactin complex 50 kD subunit
- p50/dynamitin
- dynactin subunit 2-A
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