DUX4 Products
(Double Homeobox 4 (DUX4))
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This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
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Featured DUX4 Categories
DUX4 Antibodies
High quality antibodies with extensive validation data.
Recommended DUX4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (3)
Cat. No.
ABIN655583
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN863109
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7150619
Quantity
100 μg
Datasheet
Datasheet
Recommended DUX4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352160
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our DUX4 products
: "Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study." in: Oncotarget, Vol. 8, Issue 60, pp. 101572-101590, (2017) (PubMed).: "Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model." in: Cell reports, Vol. 15, Issue 10, pp. 2301-2312, (2017) (PubMed).
: "Immunodetection of human double homeobox 4." in: Hybridoma (2005), Vol. 30, Issue 2, pp. 125-30, (2011) (PubMed).
: "Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene." in: PLoS genetics, Vol. 6, Issue 10, pp. e1001181, (2010) (PubMed).
Synonyms and alternative names related to DUX4
double homeobox, 4 (DUX4), double homeobox 4 (DUX4), DUX4, DUX4LProtein level used designations for DUX4
- double homeobox, 4
- Double homeobox protein 10
- double homeobox 4-like
- double homeobox protein 10
- double homeobox protein 4
- double homeobox protein 4/10
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