DUSP5 Products
(Dual Specificity Phosphatase 5 (DUSP5))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008].
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Featured DUSP5 Categories
DUSP5 Antibodies
High quality antibodies with extensive validation data.
DUSP5 ELISA Kits
Reliable ELISA kits for a wide range of species.
DUSP5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (6)
Cat. No.
ABIN560667
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN560666
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p)
Validations
- (1)
- (1)
Cat. No.
ABIN1713770
Quantity
100 μL
Datasheet
Datasheet
Recommended DUSP5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966429
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955466
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955467
Quantity
96 tests
Datasheet
Datasheet
Recommended DUSP5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352138
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398719
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398722
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DUSP5 products
: "Down-regulation of dual-specificity phosphatase 5 predicts poor prognosis of patients with prostate cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 4186-94, (2015) (PubMed).: "Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats." in: PLoS ONE, Vol. 9, Issue 11, pp. e112878, (2014) (PubMed).
: "DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis." in: Oncogene, Vol. 28, Issue 29, pp. 2667-77, (2009) (PubMed).
: "Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1830-45, (2005) (PubMed).
: "Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53." in: Oncogene, Vol. 22, Issue 36, pp. 5586-91, (2003) (PubMed).
Synonyms and alternative names related to DUSP5
dual specificity phosphatase 5 (DUSP5), dual specificity phosphatase 5 (dusp5), dual specificity phosphatase 5 S homeolog (dusp5.S), dual specificity phosphatase 5 (Dusp5), Cpg21, dusp, DUSP, DUSP5, Gm337, hvh3, HVH3, MGC84792, wu:fc03b11, wu:fc86e02Protein level used designations for DUSP5
- dual specificity protein phosphatase 5-like
- dual specificity phosphatase 5
- dual specificity protein phosphatase 5
- VH1-like phosphatase 3
- dual specificity protein phosphatase hVH3
- serine/threonine specific protein phosphatase
- MAP-kinase phosphatase (cpg21)
- MAP-kinase phosphatase CPG21
- candidate plasticity-related gene 21
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