DUSP12 Products
(Dual Specificity Phosphatase 12 (DUSP12))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008].
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Featured DUSP12 Categories
DUSP12 Antibodies
High quality antibodies with extensive validation data.
DUSP12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP, IF
Validations
- (3)
Cat. No.
ABIN524689
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN524688
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (1)
Cat. No.
ABIN1537912
Quantity
400 μL
Datasheet
Datasheet
Recommended DUSP12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352104
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352106
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3079207
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUSP12 products
: "Dual-specificity phosphatases: critical regulators with diverse cellular targets." in: The Biochemical journal, Vol. 418, Issue 3, pp. 475-89, (2009) (PubMed).: "Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses." in: Nature reviews. Drug discovery, Vol. 6, Issue 5, pp. 391-403, (2007) (PubMed).
: "Characterization of rat LECAM-1 (L-selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera." in: European journal of immunology, Vol. 23, Issue 9, pp. 2181-8, (1993) (PubMed).
Synonyms and alternative names related to DUSP12
dual specificity phosphatase 12 (DUSP12), dual specificity phosphatase 12 (dusp12), dual specificity phosphatase 12 L homeolog (dusp12.L), Dual specificity protein phosphatase 12 (GL50803_36315), dual specificity protein phosphatase 12 (MGYG_01770), dual specificity phosphatase 12 (Dusp12), 1190004O14Rik, AA027408, AW049275, DUSP1, DUSP12, dusp12, ESTM36, GKAP, LMW-DSP4, MGC154526, mVH1, T-DSP4, VH1, YVH1, zgc:114069Protein level used designations for DUSP12
- dual specificity phosphatase 12
- dual specificity protein phosphatase 12
- Dual specificity protein phosphatase 12
- dual specificity protein phosphatase 12-like
- YVH1 protein-tyrosine phosphatase ortholog
- dual specificity tyrosine phosphatase YVH1
- serine/threonine specific protein phosphatase
- dual specificity phosphatase T-DSP4
- dual specificity phosphatase VH1
- glucokinase-associated dual specificity phosphatase
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