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DUSP1 Products

(Dual Specificity Phosphatase 1 (DUSP1))
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008].

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Featured DUSP1 Categories

DUSP1 Antibodies

High quality antibodies with extensive validation data.

DUSP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DUSP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DUSP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (5)
Cat. No. ABIN184638
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
  • (3)
Cat. No. ABIN735368
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (3)
Cat. No. ABIN515099
Quantity 100 μg
Datasheet Datasheet

Recommended DUSP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955464
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955465
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381321
Quantity 96 tests
Datasheet Datasheet

Recommended DUSP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352094
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352096
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396922
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DUSP1 products

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." in: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: "Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis." in: Oncotarget, Vol. 7, Issue 2, pp. 2009-21, (2016) (PubMed).

Udgata, Qureshi, Mukhopadhyay: "Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 5, pp. 1776-87, (2016) (PubMed).

Chao, Sun, Peng, Wu: "Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells." in: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).

Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: "MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity." in: American journal of physiology. Endocrinology and metabolism, pp. ajpendo.00577.2013, (2014) (PubMed).

Chen, Hardy, Mendelson: "Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1)." in: The Journal of biological chemistry, Vol. 286, Issue 50, pp. 43091-102, (2011) (PubMed).

Wu, Pew, Zou, Pang, Conzen: "Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4117-24, (2005) (PubMed).

Chandrasekharan, Yang, Walters, Howe, DiCorleto: "Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46678-85, (2004) (PubMed).

Small, Shi, Edmund, Somasundaram, Moore, Orlowski: "Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role." in: Molecular pharmacology, Vol. 66, Issue 6, pp. 1478-90, (2004) (PubMed).

Alessi, Smythe, Keyse: "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts." in: Oncogene, Vol. 8, Issue 7, pp. 2015-20, (1993) (PubMed).

Synonyms and alternative names related to DUSP1

dual specificity phosphatase 1 (DUSP1), dual specificity phosphatase 1 (Dusp1), dual specificity phosphatase 1 (dusp1), dual specificity phosphatase 1 S homeolog (dusp1.S), 3CH134, cb269, CL100, DUSP1, erp, HVH1, id:ibd2586, MKP-1, mkp-1, MKP1, Mkp1, PTPN10, Ptpn16, sb:cb269, U19515, wu:fd19g02, wu:fe50g09, XCL100, zgc:55920

Protein level used designations for DUSP1

  • MAP kinase phosphatase 1
  • dual specificity protein phosphatase 1
  • dual specificity protein phosphatase hVH1
  • mitogen-activated protein kinase phosphatase 1
  • protein-tyrosine phosphatase CL100
  • serine/threonine specific protein phosphatase
  • 3CH134/CL100 PTPase
  • MAP kinase phosphatase-1
  • mitogen-activated protein (MAP) kinase phosphatase-1
  • oxidative stress-inducible protein tyrosine phosphatase
  • protein tyrosine phosphatase non-receptor type 16
  • protein tyrosine phosphatase, non-receptor type 16
  • protein-tyrosine phosphatase non-receptor type 16
  • dual specificity phosphatase 1
  • mitogen-activated protein kinase phosphatase-1
  • protein-tyrosine phosphatase 3CH134
  • protein-tyrosine phosphatase ERP
  • mkp-1
  • MAPK phosphatase 1
  • LOW QUALITY PROTEIN: dual specificity protein phosphatase 1
  • MAP kinase phosphatase XCL100(beta) protein
  • XCL100-beta
  • dual specificity protein phosphatase 1-B
  • dusp1-b
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