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Dual Specificity Phosphatase 3 Products

(Dual Specificity Phosphatase 3 (DUSP3))
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].

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Featured Dual Specificity Phosphatase 3 Categories

Dual Specificity Phosphatase 3 Antibodies

High quality antibodies with extensive validation data.

Dual Specificity Phosphatase 3 ELISA Kits

Reliable ELISA kits for a wide range of species.

Dual Specificity Phosphatase 3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Dual Specificity Phosphatase 3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (4)
Cat. No. ABIN7426586
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN392924
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN560661
Quantity 50 μg
Datasheet Datasheet

Recommended Dual Specificity Phosphatase 3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5591980
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4885040
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6203853
Quantity 96 tests
Datasheet Datasheet

Recommended Dual Specificity Phosphatase 3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122713
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352132
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352134
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Dual Specificity Phosphatase 3 products

Wang, Yeh, Chou, Yang, Fu, Chen, Cheng, Huang, Liu, Huang, Chen: "Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer." in: The Journal of biological chemistry, Vol. 286, Issue 12, pp. 10177-84, (2011) (PubMed).

Tabernero, Aricescu, Jones, Szedlacsek: "Protein tyrosine phosphatases: structure-function relationships." in: The FEBS journal, Vol. 275, Issue 5, pp. 867-82, (2008) (PubMed).

Alonso, Rahmouni, Williams, van Stipdonk, Jaroszewski, Godzik, Abraham, Schoenberger, Mustelin: "Tyrosine phosphorylation of VHR phosphatase by ZAP-70." in: Nature immunology, Vol. 4, Issue 1, pp. 44-8, (2002) (PubMed).

Alonso, Saxena, Williams, Mustelin: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, (2001) (PubMed).

Yuvaniyama, Denu, Dixon, Saper: "Crystal structure of the dual specificity protein phosphatase VHR." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1328-31, (1996) (PubMed).

Aroca, Bottaro, Ishibashi, Aaronson, Santos: "Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14229-34, (1995) (PubMed).

Ishibashi, Bottaro, Chan, Miki, Aaronson: "Expression cloning of a human dual-specificity phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 12170-4, (1993) (PubMed).

Synonyms and alternative names related to Dual Specificity Phosphatase 3

dual specificity phosphatase 3 (DUSP3), dual specificity phosphatase 3b (dusp3b), dual specificity phosphatase 3 (Dusp3), dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), 2210015O03Rik, 5031436O03Rik, dusp3, RGD1560049, si:bz18k17.3, si:rp71-18k17.3, T-DSP11, VHR

Protein level used designations for Dual Specificity Phosphatase 3

  • dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
  • dual specificity phosphatase 3
  • dual specificity protein phosphatase 3
  • dual specificity protein phosphatase VHR
  • serine/threonine specific protein phosphatase
  • vaccinia H1-related phosphatase
  • vaccinia virus phosphatase VH1-related
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