Dual Specificity Phosphatase 3 Products
(Dual Specificity Phosphatase 3 (DUSP3))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
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Featured Dual Specificity Phosphatase 3 Categories
Dual Specificity Phosphatase 3 Antibodies
High quality antibodies with extensive validation data.
Dual Specificity Phosphatase 3 ELISA Kits
Reliable ELISA kits for a wide range of species.
Dual Specificity Phosphatase 3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Dual Specificity Phosphatase 3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (4)
Cat. No.
ABIN7426586
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN392924
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN560661
Quantity
50 μg
Datasheet
Datasheet
Recommended Dual Specificity Phosphatase 3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5591980
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4885040
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6203853
Quantity
96 tests
Datasheet
Datasheet
Recommended Dual Specificity Phosphatase 3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122713
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352132
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352134
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Dual Specificity Phosphatase 3 products
: "Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer." in: The Journal of biological chemistry, Vol. 286, Issue 12, pp. 10177-84, (2011) (PubMed).: "Protein tyrosine phosphatases: structure-function relationships." in: The FEBS journal, Vol. 275, Issue 5, pp. 867-82, (2008) (PubMed).
: "Tyrosine phosphorylation of VHR phosphatase by ZAP-70." in: Nature immunology, Vol. 4, Issue 1, pp. 44-8, (2002) (PubMed).
: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, (2001) (PubMed).
: "Crystal structure of the dual specificity protein phosphatase VHR." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1328-31, (1996) (PubMed).
: "Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14229-34, (1995) (PubMed).
: "Expression cloning of a human dual-specificity phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 12170-4, (1993) (PubMed).
Synonyms and alternative names related to Dual Specificity Phosphatase 3
dual specificity phosphatase 3 (DUSP3), dual specificity phosphatase 3b (dusp3b), dual specificity phosphatase 3 (Dusp3), dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), 2210015O03Rik, 5031436O03Rik, dusp3, RGD1560049, si:bz18k17.3, si:rp71-18k17.3, T-DSP11, VHRProtein level used designations for Dual Specificity Phosphatase 3
- dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
- dual specificity phosphatase 3
- dual specificity protein phosphatase 3
- dual specificity protein phosphatase VHR
- serine/threonine specific protein phosphatase
- vaccinia H1-related phosphatase
- vaccinia virus phosphatase VH1-related
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