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DRAP1 Products

(DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008].

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Featured DRAP1 Categories

DRAP1 Antibodies

High quality antibodies with extensive validation data.

DRAP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DRAP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DRAP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
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Cat. No. ABIN564619
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
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Cat. No. ABIN1538849
Quantity 400 μL
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Application WB
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  • (1)
Cat. No. ABIN6741729
Quantity 100 μL
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Recommended DRAP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1130683
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1130684
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1130685
Quantity 96 tests
Datasheet Datasheet

Recommended DRAP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
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Cat. No. ABIN1352006
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352008
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (5)
  • (1)
Cat. No. ABIN1046948
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DRAP1 products

Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, (2011) (PubMed).

Klejman, Pereira, van Zeeburg, Gilfillan, Meisterernst, Timmers: "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10072-82, (2004) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Goppelt, Stelzer, Lottspeich, Meisterernst: "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains." in: The EMBO journal, Vol. 15, Issue 12, pp. 3105-16, (1996) (PubMed).

Mermelstein, Yeung, Cao, Inostroza, Erdjument-Bromage, Eagelson, Landsman, Levitt, Tempst, Reinberg: "Requirement of a corepressor for Dr1-mediated repression of transcription." in: Genes & development, Vol. 10, Issue 8, pp. 1033-48, (1996) (PubMed).

Synonyms and alternative names related to DRAP1

DR1-associated protein 1 (negative cofactor 2 alpha) (drap1), DR1 associated protein 1 (DRAP1), Dr1 associated protein 1 (negative cofactor 2 alpha) (Drap1), Dr1 associated protein 1 (Drap1), 2310074H19Rik, DRAP1, fb26e10, NC2-alpha, wu:fb26e10, zgc:56003, zgc:77337

Protein level used designations for DRAP1

  • dr1-associated corepressor
  • DR1-associated protein 1 (negative cofactor 2 alpha)
  • NC2-alpha
  • dr1-associated protein 1
  • negative co-factor 2-alpha
  • negative cofactor 2 alpha
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