DR3/LARD Products
(Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
Categories
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008].
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Featured DR3/LARD Categories
DR3/LARD Antibodies
High quality antibodies with extensive validation data.
DR3/LARD ELISA Kits
Reliable ELISA kits for a wide range of species.
DR3/LARD Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DR3/LARD Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IHC
Validations
- (6)
Cat. No.
ABIN7193676
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (3)
Cat. No.
ABIN668421
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7271071
Quantity
100 μL
Datasheet
Datasheet
Recommended DR3/LARD ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6973621
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510736
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510683
Quantity
96 tests
Datasheet
Datasheet
Recommended DR3/LARD Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274495
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092807
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323193
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our DR3/LARD products
: "TL1A as a potential local inducer of IL17A Expression in colon mucosa of inflammatory bowel disease patients." in: Scandinavian journal of immunology, (2015) (PubMed).: "Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia." in: Oncotarget, Vol. 6, Issue 31, pp. 32061-74, (2015) (PubMed).
: "The TNF-family cytokine TL1A inhibits proliferation of human activated B cells." in: PLoS ONE, Vol. 8, Issue 4, pp. e60136, (2013) (PubMed).
: "Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells." in: International journal of oncology, Vol. 38, Issue 6, pp. 1565-73, (2011) (PubMed).
: "Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 409-19, (2011) (PubMed).
: "Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3." in: BMC cancer, Vol. 11, pp. 285, (2011) (PubMed).
: "TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells." in: Cellular immunology, Vol. 266, Issue 1, pp. 61-6, (2010) (PubMed).
: "Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action." in: Cancer research, Vol. 64, Issue 3, pp. 1122-9, (2004) (PubMed).
: "Stable and unstable pools of Myc protein exist in human cells." in: Oncogene, Vol. 21, Issue 55, pp. 8515-20, (2002) (PubMed).
: "Multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 734-43, (2002) (PubMed).
Synonyms and alternative names related to DR3/LARD
TNF receptor superfamily member 25 (TNFRSF25), tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25), TNF receptor superfamily member 25 (Tnfrsf25), APO-3, DDR3, DR3, LARD, TNFRSF12, Tnfrsf12, TNFRSF25, TR3, TRAMP, Wsl, WSL-1, WSL-LRProtein level used designations for DR3/LARD
- apoptosis inducing receptor
- apoptosis-inducing receptor AIR
- apoptosis-mediating receptor DR3
- apoptosis-mediating receptor TRAMP
- death domain receptor 3 soluble form
- death receptor beta
- lymphocyte-associated receptor of death
- protein WSL-1
- tumor necrosis factor receptor superfamily member 25
- tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- tumor necrosis factor receptor superfamily, member 12
- tumor necrosis factor receptor superfamily, member 25
- translocating chain-association membrane protein
- tumor necrosis factor receptor superfamily, member12
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