DOT1L Products
(DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
Categories
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].
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Featured DOT1L Categories
DOT1L Antibodies
High quality antibodies with extensive validation data.
DOT1L ELISA Kits
Reliable ELISA kits for a wide range of species.
DOT1L Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DOT1L Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
Cat. No.
ABIN566567
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7155530
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC (p)
Validations
- (2)
- (1)
Cat. No.
ABIN6243177
Quantity
400 μL
Datasheet
Datasheet
Recommended DOT1L ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955450
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955451
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5653731
Quantity
96 tests
Datasheet
Datasheet
Recommended DOT1L Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351915
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2669718
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7317542
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our DOT1L products
: "miR-133b suppresses colorectal cancer cell stemness and chemoresistance by targeting methyltransferase DOT1L." in: Experimental cell research, Vol. 385, Issue 1, pp. 111597, (2019) (PubMed).: "An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy." in: Oncotarget, Vol. 9, Issue 27, pp. 19079-19099, (2018) (PubMed).
: "2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls." in: Respiratory research, Vol. 18, Issue 1, pp. 81, (2018) (PubMed).
: "Copy-number variation and protein expression of DOT1L in pancreatic adenocarcinoma as a potential drug target." in: Molecular and clinical oncology, Vol. 6, Issue 5, pp. 639-642, (2017) (PubMed).
: "Functional interdependence of BRD4 and DOT1L in MLL leukemia. ..." in: Nature structural & molecular biology, Vol. 23, Issue 7, pp. 673-81, (2016) (PubMed).
: "Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis." in: Journal of assisted reproduction and genetics, Vol. 33, Issue 6, pp. 783-94, (2016) (PubMed).
: "Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack." in: PLoS genetics, Vol. 9, Issue 7, pp. e1003611, (2013) (PubMed).
: "Polycomb eviction as a new distant enhancer function." in: Genes & development, Vol. 25, Issue 15, pp. 1583-8, (2011) (PubMed).
: "A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41195-204, (2011) (PubMed).
: "DOT1L regulates dystrophin expression and is critical for cardiac function." in: Genes & development, Vol. 25, Issue 3, pp. 263-74, (2011) (PubMed).
Synonyms and alternative names related to DOT1L
histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC100116648), DOT1 like histone lysine methyltransferase (DOT1L), histone methyltransferase (DOT1), DOT1 like histone lysine methyltransferase (Dot1l), DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l), A630076O07, AW907654, DOT1, Dot1, DOT1L, KMT4, mDot1, NV11307Protein level used designations for DOT1L
- histone-lysine N-methyltransferase, H3 lysine-79 specific
- DOT1-like, histone H3 methyltransferase (S. cerevisiae)
- histone-lysine N-methyltransferase, H3 lysine-79 specific-like
- possible nucleosomal histone methylase
- DOT1-like protein
- DOT1-like, histone H3 methyltransferase
- H3-K79-HMTase
- histone H3-K79 methyltransferase
- histone methyltransferase DOT1L
- lysine N-methyltransferase 4
- DOT1-like histone H3 methyltransferase
- histone H3 methyltransferase DOT1
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