DOM34 Proteins
(Ribosome Dissociation Factor DOM34 (DOM34))
Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double- stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions. {ECO:0000269|PubMed:16554824, ECO:0000269|PubMed:17889667, ECO:0000269|PubMed:18180287}.
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