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DOK2 Products

(DOK2)
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008].

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Featured DOK2 Categories

DOK2 Antibodies

High quality antibodies with extensive validation data.

DOK2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DOK2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DOK2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7150566
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN684148
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN392072
Quantity 400 μL
Datasheet Datasheet

Recommended DOK2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380557
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5593715
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1130515
Quantity 96 tests
Datasheet Datasheet

Recommended DOK2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351902
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3078950
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3132011
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DOK2 products

Honma, Higuchi, Shirakata, Yasuda, Shibuya, Iemura, Natsume, Yamanashi: "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 11, Issue 2, pp. 143-51, (2006) (PubMed).

Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 443-8, (2003) (PubMed).

Cong, Yuan, Goff: "Characterization of a novel member of the DOK family that binds and modulates Abl signaling." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8314-25, (2000) (PubMed).

Schaeper, Gehring, Fuchs, Sachs, Kempkes, Birchmeier: "Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses." in: The Journal of cell biology, Vol. 149, Issue 7, pp. 1419-32, (2000) (PubMed).

Di Cristofano, Carpino, Dunant, Friedland, Kobayashi, Strife, Wisniewski, Clarkson, Pandolfi, Resh: "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins." in: The Journal of biological chemistry, Vol. 273, Issue 9, pp. 4827-30, (1998) (PubMed).

Jones, Dumont: "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R." in: Oncogene, Vol. 17, Issue 9, pp. 1097-108, (1998) (PubMed).

Nelms, Snow, Hu-Li, Paul: "FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation." in: Immunity, Vol. 9, Issue 1, pp. 13-24, (1998) (PubMed).

Synonyms and alternative names related to DOK2

docking protein 2 (DOK2), docking protein 2 (Dok2), Dok-2, DokR, Frip, p56DOK, p56dok-2

Protein level used designations for DOK2

  • IL-Four Receptor Interacting Protein
  • IL-four receptor-interacting protein
  • dok-R
  • dok-related protein
  • downstream of tyrosine kinase 2
  • p56 dok-2
  • p56(dok-2)
  • docking protein 2
  • Downstream of tyrosine kinase 2
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