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DOK1 Products

(Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

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The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

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Featured DOK1 Categories

DOK1 Antibodies

High quality antibodies with extensive validation data.

DOK1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DOK1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DOK1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN6139763
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6263984
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7261640
Quantity 200 μL
Datasheet Datasheet

Recommended DOK1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380555
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380556
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1130511
Quantity 96 tests
Datasheet Datasheet

Recommended DOK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351900
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423414
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418881
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DOK1 products

Sarin, Engel, Rothweiler, Cinatl, Michaelis, Frötschl, Fröhlich, Kalayda: "Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach." in: International journal of molecular sciences, Vol. 19, Issue 3, (2018) (PubMed).

Barrett, Evans, Frolov, Britton, Pellet-Many, Yamaji, Mehta, Bandopadhyay, Li, Brandner, Zachary, Frankel: "A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling." in: Journal of cell science, Vol. 127, Issue Pt 12, pp. 2647-58, (2014) (PubMed).

Simoncic, Bourdeau, Lee-Loy, Rohrschneider, Tremblay, Stanley, McGlade: "T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4149-60, (2006) (PubMed).

Yopp, Ochando, Mao, Ledgerwood, Ding, Bromberg: "Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2913-24, (2005) (PubMed).

Dubé, Cheng, Tremblay: "The role of protein tyrosine phosphatase 1B in Ras signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 1834-9, (2004) (PubMed).

Woodring, Meisenhelder, Johnson, Zhou, Field, Shah, Bladt, Pawson, Niki, Pandolfi, Wang, Hunter: "c-Abl phosphorylates Dok1 to promote filopodia during cell spreading." in: The Journal of cell biology, Vol. 165, Issue 4, pp. 493-503, (2004) (PubMed).

Lee, Andrieu, Saltel, Destaing, Auclair, Pouchkine, Michelon, Salaun, Kobayashi, Jurdic, Kieff, Sylla: "IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 50, pp. 17416-21, (2004) (PubMed).

Kato, Takai, Kudo: "The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 629-34, (2002) (PubMed).

Liang, Wisniewski, Strife, Shivakrupa, Clarkson, Resh: "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13732-8, (2002) (PubMed).

Yamakawa, Tsuchida, Sugino: "The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors." in: The EMBO journal, Vol. 21, Issue 7, pp. 1684-94, (2002) (PubMed).

Synonyms and alternative names related to DOK1

docking protein 1 (DOK1), docking protein 1 (Dok1), docking protein 1b (dok1b), AW557123, Dok-1, dok1, P62DOK, p62DOK, zgc:76914

Protein level used designations for DOK1

  • Downstream of tyrosine kinase 1
  • docking protein 1
  • docking protein 1 (downstream of tyrosine kinase 1)
  • p62(dok)
  • pp62
  • downstream of tyrosine kinase 1
  • downstream of tyrosine kinase-1
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