DNASE1 Products
(Deoxyribonuclease I (DNASE1))
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This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
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Featured DNASE1 Categories
DNASE1 Antibodies
High quality antibodies with extensive validation data.
DNASE1 ELISA Kits
Reliable ELISA kits for a wide range of species.
DNASE1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DNASE1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433180
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ICC, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN2856669
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN3016215
Quantity
100 μL
Datasheet
Datasheet
Recommended DNASE1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN6574255
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966327
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966325
Quantity
96 tests
Datasheet
Datasheet
Recommended DNASE1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122635
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351834
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505085
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DNASE1 products
: "Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of normal human CD4+ T-lymphocytes." in: Biochimie, Vol. 174, pp. 34-43, (2021) (PubMed).: "Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried." in: Scientific reports, Vol. 10, Issue 1, pp. 13088, (2020) (PubMed).
: "Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure." in: Journal of cardiac failure, Vol. 22, Issue 10, pp. 823-8, (2016) (PubMed).
: "Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease." in: Investigative ophthalmology & visual science, Vol. 53, Issue 13, pp. 8253-63, (2012) (PubMed).
: "Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c." in: The Journal of biological chemistry, Vol. 266, Issue 4, pp. 2134-42, (1991) (PubMed).
: "A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells." in: European journal of immunology, Vol. 21, Issue 1, pp. 143-51, (1991) (PubMed).
Synonyms and alternative names related to DNASE1
DNase I (endA), DNase I (LOC397802), deoxyribonuclease 1 (DNASE1), deoxyribonuclease I (Dnase1), deoxyribonuclease 1 (Dnase1), deoxyribonuclease I L homeolog (dnase1.L), deoxyribonuclease I (dnase1), deoxyribonuclease I (CpipJ_CPIJ011184), deoxyribonuclease I (CpipJ_CPIJ011185), deoxyribonuclease I (CpipJ_CPIJ011186), deoxyribonuclease I (CpipJ_CPIJ011187), deoxyribonuclease I (CpipJ_CPIJ011190), deoxyribonuclease I (CpipJ_CPIJ017803), Deoxyribonuclease I (Desal_1409), deoxyribonuclease I (MPET_RS05255), deoxyribonuclease I (METEV_RS02275), deoxyribonuclease I (Plabr_0631), AI788650, dnase1-A, DNaseI, DNL1, Dnl1, DRNI, LOC397802, zgc:92440Protein level used designations for DNASE1
- DNase I
- DNase I, lysosomal
- Dornase alfa
- deoxyribonuclease-1
- human urine deoxyribonuclease I
- deoxyribonuclease I
- Deoxyribonuclease I
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