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DMPK Products

(Dystrophia Myotonica-Protein Kinase (DMPK))

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The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].

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Featured DMPK Categories

DMPK Antibodies

High quality antibodies with extensive validation data.

DMPK ELISA Kits

Reliable ELISA kits for a wide range of species.

DMPK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DMPK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (6)
Cat. No. ABIN7073790
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (5)
Cat. No. ABIN950119
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (4)
Cat. No. ABIN515032
Quantity 100 μg
Datasheet Datasheet

Recommended DMPK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648192
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1143793
Quantity 96 tests
Datasheet Datasheet

Recommended DMPK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351723
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508895
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423321
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DMPK products

Ramasamy, Ren, Mench, Regan: "Impact of initial biofilm growth on the anode impedance of microbial fuel cells." in: Biotechnology and bioengineering, Vol. 101, Issue 1, pp. 101-8, (2008) (PubMed).

Jin, Shimizu, Balasubramanyam, Epstein: "Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells." in: Cell motility and the cytoskeleton, Vol. 45, Issue 2, pp. 133-48, (2000) (PubMed).

Pham, Man, Lam, Morris: "Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies." in: Human molecular genetics, Vol. 7, Issue 12, pp. 1957-65, (1998) (PubMed).

Mahadevan, Amemiya, Jansen, Sabourin, Baird, Neville, Wormskamp, Segers, Batzer, Lamerdin: "Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene." in: Human molecular genetics, Vol. 2, Issue 3, pp. 299-304, (1993) (PubMed).

Synonyms and alternative names related to DMPK

DM1 protein kinase (DMPK), dystrophia myotonica-protein kinase (Dmpk), DM1 protein kinase (Dmpk), DM, DM1, DM1PK, Dm15, DMK, DMPK, MDPK, MT-PK

Protein level used designations for DMPK

  • dystrophia myotonica-protein kinase
  • myotonic dystrophy protein kinase
  • myotonin-protein kinase-like
  • DM protein kinase
  • DM-kinase
  • DM1 protein kinase
  • myotonic dystrophy associated protein kinase
  • myotonin protein kinase A
  • myotonin-protein kinase
  • thymopoietin homolog
  • dystrophia myotonica kinase, B15
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