DLAT Products
(Dihydrolipoyl Transacetylase (DLAT))
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This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009].
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Featured DLAT Categories
DLAT Antibodies
High quality antibodies with extensive validation data.
DLAT ELISA Kits
Reliable ELISA kits for a wide range of species.
DLAT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DLAT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7432412
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7257932
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7266768
Quantity
100 μL
Datasheet
Datasheet
Recommended DLAT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966368
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955387
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1114634
Quantity
96 tests
Datasheet
Datasheet
Recommended DLAT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122666
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351656
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7403039
Quantity
100 μg
Datasheet
Datasheet
Synonyms and alternative names related to DLAT
midline uncoordinated (muc), dihydrolipoamide S-acetyltransferase L homeolog (dlat.L), dihydrolipoamide S-acetyltransferase (DLAT), dihydrolipoamide S-acetyltransferase (Dlat), dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat), dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), 6332404G05Rik, anon-WO0118547.121, DLAT, DLTA, Dmel\\CG5261, EP(2)0816, EP816, PDC-E2, PDCE2, wu:fc14f10, wu:fc21f08, wu:fc86g11, wu:fj57d06Protein level used designations for DLAT
- CG5261-PA
- CG5261-PB
- CG5261-PC
- CG5261-PD
- CG5261-PE
- CG5261-PF
- Dihydrolipoyllysine-residue acetyltransferase
- dihydrolipoamide acetyltransferase
- dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- 70 kDa mitochondrial autoantigen of primary biliary cirrhosis
- E2 component of pyruvate dehydrogenase complex
- M2 antigen complex 70 kDa subunit
- PBC
- dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
- dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial
- dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
- pyruvate dehydrogenase complex component E2
- dihydrolipoyllysine-residue acetyltransferase
- E2
- PDC-E2
- PDCE2
- fc86g11
- fj57d06
- no optokinetic nystagmus a
- no optokinetic response b
- noa
- nrb
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