DKK2 Products
(Dickkopf 2 Homolog (DKK2))
Categories
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008].
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Featured DKK2 Categories
DKK2 Antibodies
High quality antibodies with extensive validation data.
DKK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DKK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DKK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7149882
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6749760
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7433045
Quantity
100 μL
Datasheet
Datasheet
Recommended DKK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6955381
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966354
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966352
Quantity
96 tests
Datasheet
Datasheet
Recommended DKK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122658
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN6964354
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7539309
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our DKK2 products
: "Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1." in: Nature cell biology, Vol. 19, Issue 10, pp. 1274-1285, (2017) (PubMed).: "Rheumatoid arthritis bone fragility is associated with upregulation of IL17 and DKK1 gene expression." in: Clinical reviews in allergy & immunology, Vol. 47, Issue 1, pp. 38-45, (2014) (PubMed).
: "DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma." in: Cancer research, Vol. 73, Issue 2, pp. 967-77, (2013) (PubMed).
: "Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells." in: British journal of cancer, Vol. 108, Issue 10, pp. 2070-8, (2013) (PubMed).
: "Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma." in: Carcinogenesis, Vol. 33, Issue 12, pp. 2334-43, (2012) (PubMed).
: "Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development." in: International journal of oncology, Vol. 37, Issue 6, pp. 1495-501, (2011) (PubMed).
: "Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 18, pp. 5678-87, (2009) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6100-10, (2002) (PubMed).
: "Functional and structural diversity of the human Dickkopf gene family." in: Gene, Vol. 238, Issue 2, pp. 301-13, (1999) (PubMed).
Synonyms and alternative names related to DKK2
dickkopf WNT signaling pathway inhibitor 2 (DKK2), dickkopf WNT signaling pathway inhibitor 2 (Dkk2), dickkopf WNT signaling pathway inhibitor 2 (dkk2), DKK-2, Dkk4, zgc:171574Protein level used designations for DKK2
- dickkopf 2 homolog
- dickkopf homolog 2
- dickkopf related protein-2
- dickkopf-2
- dickkopf-related protein 2
- hDkk-2
- dickkopf 2
- dickkopf homolog 1
- dkk-2
- mDkk-2
- dickkopf homolog 4
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