DIS3 Products
(Exosome Complex Exonuclease RRP44 (DIS3))
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Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).
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Featured DIS3 Categories
DIS3 Antibodies
High quality antibodies with extensive validation data.
DIS3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DIS3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (2)
Cat. No.
ABIN524835
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN524836
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN654155
Quantity
400 μL
Datasheet
Datasheet
Recommended DIS3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228991
Quantity
96 tests
Datasheet
Datasheet
Recommended DIS3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351629
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095104
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137036
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DIS3 products
: "Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome." in: Nucleic acids research, Vol. 42, Issue 11, pp. 7358-69, (2014) (PubMed).: "Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target." in: Nucleic acids research, Vol. 42, Issue 2, pp. 1270-90, (2014) (PubMed).
: "Mammalian 5'-capped microRNA precursors that generate a single microRNA." in: Cell, Vol. 155, Issue 7, pp. 1568-80, (2013) (PubMed).
: "The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control." in: Molecular and cellular biology, Vol. 11, Issue 12, pp. 5839-47, (1991) (PubMed).
Synonyms and alternative names related to DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3), DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (dis3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (dis3.L), 2810028N01Rik, bA555G22.1, DIS3, dis3, dis3p, EXOSC11, KIAA1008, RGD1304646, RP11-342J4.3, RRP44, wu:fb08g12Protein level used designations for DIS3
- 2810028N01Rik
- exosome complex exonuclease RRP44
- exosome component 11
- mitotic control protein dis3 homolog
- protein DIS3 homolog
- ribosomal RNA-processing protein 44
- DIS3 mitotic control homolog (S. cerevisiae)
- DIS3 mitotic control homolog
- DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
- DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
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