DIABLO Products
(Second Mitochondria-Derived Activator of Caspase (DIABLO))
Categories
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008].
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Featured DIABLO Categories
DIABLO Antibodies
High quality antibodies with extensive validation data.
DIABLO ELISA Kits
Reliable ELISA kits for a wide range of species.
DIABLO Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DIABLO Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (1)
- (4)
Cat. No.
ABIN6243156
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (5)
Cat. No.
ABIN3023379
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN7211360
Quantity
100 μg
Datasheet
Datasheet
Recommended DIABLO ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959278
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959279
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN625468
Quantity
96 tests
Datasheet
Datasheet
Recommended DIABLO Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124996
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351587
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667710
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DIABLO products
: "Mesenchymal stem cells expressing interleukin-18 inhibit breast cancer in a mouse model." in: Oncology letters, Vol. 15, Issue 5, pp. 6265-6274, (2018) (PubMed).: "Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers." in: BMC neuroscience, Vol. 18, Issue 1, pp. 12, (2017) (PubMed).
: "Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome." in: Toxicology and applied pharmacology, (2016) (PubMed).
: "N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis." in: Journal of neurochemistry, Vol. 134, Issue 5, pp. 956-68, (2015) (PubMed).
: "SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas." in: Molecular cancer, Vol. 14, pp. 78, (2015) (PubMed).
: "A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 13, Issue 3, pp. 565-75, (2014) (PubMed).
: "Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 21, pp. 7594-9, (2014) (PubMed).
: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, (2013) (PubMed).
: "An apoptosis-independent role of SMAC in tumor suppression." in: Oncogene, Vol. 32, Issue 19, pp. 2380-9, (2013) (PubMed).
: "Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis." in: Neurobiology of disease, Vol. 55, pp. 26-35, (2013) (PubMed).
Synonyms and alternative names related to DIABLO
diablo, IAP-binding mitochondrial protein (diablo), diablo, IAP-binding mitochondrial protein (Diablo), diablo IAP-binding mitochondrial protein (DIABLO), diablo, IAP-binding mitochondrial protein L homeolog (diablo.L), 0610041G12Rik, 1700006L01Rik, AU040403, DBO, DFNA64, diablo-s, smac, Smac, SMAC, smac3, XSmacProtein level used designations for DIABLO
- Direct IAP-binding protein with low pI
- diablo homolog, mitochondrial
- second mitochondria-derived activator of caspase
- direct IAP binding protein with low PI
- direct IAP-binding protein with low pI
- diablo homolog
- mitochondrial diablo-like protein
- mitochondrial diablo
- second mitochondrial derived activator of caspases
- Second mitochondria-derived activator of caspase
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