Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

DHX58 Proteins

(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
DHX58 Protein (AA 1-678) (GST tag) DHX58 Protein (AA 1-678) (GST tag) DHX58 Protein (AA 1-678) (GST tag) (ABIN1351580)

DHX58 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3092156)

DHX58 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3136923)

DHX58 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS

DHX58 Proteins by Origin

Find DHX58 Proteins for a variety of species such as anti-Human DHX58, anti-Mouse DHX58. The species listed below are among those available. Click on a link to go to the corresponding products.

DHX58 Proteins by Source

Here you will find DHX58 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

DHX58 Proteins by Protein Type

Here you can find DHX58 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

DHX58 Proteins by Application

Find DHX58 Proteins validated for a specific application such as ELISA, WB, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular DHX58 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351580
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3092156
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136923
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2719466
Quantity 20 μg
Datasheet Datasheet

Aliases for DHX58 Proteins

DEXH-box helicase 58 L homeolog (dhx58.L) Proteins
DExH-box helicase 58 (DHX58) Proteins
DExH-box helicase 58 (dhx58) Proteins
probable ATP-dependent RNA helicase DHX58 (LOC100566102) Proteins
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) Proteins
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) Proteins
DEXH-box helicase 58 (Dhx58) Proteins
B430001I08Rik Proteins
D11LGP2 Proteins
D11lgp2e Proteins
D11Lgp2e Proteins
DHX58 Proteins
lgp2 Proteins
LGP2 Proteins
Lgp2 Proteins
LPG2 Proteins
MGC82787 Proteins
RGD1310093 Proteins
RLR-3 Proteins
You are here:
Support