DFFB Products
(DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
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Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
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Featured DFFB Categories
DFFB Antibodies
High quality antibodies with extensive validation data.
DFFB ELISA Kits
Reliable ELISA kits for a wide range of species.
DFFB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DFFB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN653798
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (4)
Cat. No.
ABIN7193449
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7150177
Quantity
100 μL
Datasheet
Datasheet
Recommended DFFB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955422
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1114002
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1114001
Quantity
96 tests
Datasheet
Datasheet
Recommended DFFB Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351482
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351481
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393079
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DFFB products
: "Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns." in: Cell death & disease, Vol. 5, pp. e1494, (2014) (PubMed).: "Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ..." in: Toxicology and applied pharmacology, Vol. 273, Issue 1, pp. 196-208, (2013) (PubMed).
: "DNA degradation in development and programmed cell death." in: Annual review of immunology, Vol. 23, pp. 853-75, (2005) (PubMed).
: "Large complex formation of the inhibitor of caspase-activated DNase." in: Apoptosis : an international journal on programmed cell death, Vol. 10, Issue 3, pp. 651-6, (2005) (PubMed).
: "Degradation of chromosomal DNA during apoptosis." in: Cell death and differentiation, Vol. 10, Issue 1, pp. 108-16, (2003) (PubMed).
: "Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37768-76, (2003) (PubMed).
: "The DFF40/CAD endonuclease and its role in apoptosis." in: Acta biochimica Polonica, Vol. 47, Issue 4, pp. 1037-44, (2002) (PubMed).
: "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13836-40, (1999) (PubMed).
: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).
: "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8461-6, (1998) (PubMed).
Synonyms and alternative names related to DFFB
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), DNA fragmentation factor subunit beta (DFFB), DNA fragmentation factor, beta polypeptide (caspase-activated DNase) (dffb), DNA fragmentation factor subunit beta (LOC100223514), DNA fragmentation factor, beta subunit (Dffb), DNA fragmentation factor subunit beta (Dffb), 40kDa, 5730477D02Rik, CAD, Cad, CPAN, DFF-40, DFF2, DFF40, Didff, LOC100223514Protein level used designations for DFFB
- CAD protein
- CAD trifunctional protein
- multifunctional protein CAD
- DNA fragmentation factor 40 kDa subunit
- DNA fragmentation factor subunit beta
- caspase-activated DNase
- caspase-activated deoxyribonuclease
- caspase-activated nuclease
- DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- DNA fragmentation factor, 40 kD, beta polypeptide
- DFF-40
- DNA fragmentation factor, 40 kD, beta subunit
- DNase inhibited by DNA fragmentation factor
- DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase)
- DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)
- DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
- DNA fragmentation factor, beta subunit
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