DERL1 Products
(Der1-Like Domain Family, Member 1 (DERL1))
Categories
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].
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Featured DERL1 Categories
DERL1 Antibodies
High quality antibodies with extensive validation data.
DERL1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DERL1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), FACS
Validations
- (4)
Cat. No.
ABIN652693
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (2)
Cat. No.
ABIN1386486
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IHC (p), FACS
Validations
- (2)
Cat. No.
ABIN1978394
Quantity
200 μL
Datasheet
Datasheet
Recommended DERL1 Proteins
Latest Publications for our DERL1 products
: "Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells." in: Scientific reports, Vol. 4, pp. 6952, (2014) (PubMed).: "HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation." in: The Journal of biological chemistry, Vol. 282, Issue 38, pp. 28285-95, (2007) (PubMed).
: "Cell biology: a channel for protein waste." in: Nature, Vol. 429, Issue 6994, pp. 817-8, (2004) (PubMed).
Synonyms and alternative names related to DERL1
Derlin-1 (Der-1), derlin-1 (EDI_023440), derlin-1.1 (PTRG_01331), hypothetical protein (derl1), Der1-like domain family, member 1 (DERL1), derlin 1 (derl1), derlin 1 L homeolog (derl1.L), derlin 1 (DERL1), Der1-like domain family, member 1 (Derl1), derlin 1 (Derl1), DERLIN-1 (DER1), 1110021N07Rik, AI195141, AW551338, CG10908, DDBDRAFT_0188135, DDBDRAFT_0266772, DDB_0188135, DDB_0266772, DER-1, DER1, Derlin-1, derlin-1, DERLIN-1, Dmel\\CG10908, F17A13.150, F17A13_150, MGC84200, RGD1311835, wu:fb09d07, wu:fb94d05, wu:fj92g12, zgc:55637Protein level used designations for DERL1
- CG10908-PA
- CG10908-PB
- Der-1-PA
- Der-1-PB
- Dm Derlin-1
- derlin-1
- derlin-1.1
- Der1-like domain family, member 1
- Der1-like protein 1
- degradation in endoplasmic reticulum protein 1
- der1-like protein 1
- DERtrin-1
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