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DDX21 Products

(DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008].

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Featured DDX21 Categories

DDX21 Antibodies

High quality antibodies with extensive validation data.

DDX21 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DDX21 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7258156
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN1539008
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN6139485
Quantity 100 μL
Datasheet Datasheet

Recommended DDX21 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6216003
Quantity 96 tests
Datasheet Datasheet

Recommended DDX21 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351333
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3092088
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3137276
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DDX21 products

Bi, Xu, Li, Li, Li, Shao, Wang, Zhan, Wu, Liu, Lu, Wang, Zhao, Wu, Na, Li, Li, Shen: "RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control." in: Molecular cell, Vol. 75, Issue 1, pp. 102-116.e9, (2019) (PubMed).

Argaud, Boulanger, Chignon, Mkannez, Mathieu: "Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription." in: Nucleic acids research, (2019) (PubMed).

Song, Hotz-Wagenblatt, Voit, Grummt: "SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability." in: Genes & development, Vol. 31, Issue 13, pp. 1370-1381, (2018) (PubMed).

Smith, Krumpelbeck, Jegga, Prell, Matrka, Kappes, Greis, Ali, Meetei, Wells: "The nuclear DEK interactome supports multi-functionality." in: Proteins, Vol. 86, Issue 1, pp. 88-97, (2018) (PubMed).

Calo, Gu, Bowen, Aryan, Zalc, Liang, Flynn, Swigut, Chang, Attardi, Wysocka: "Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders." in: Nature, Vol. 554, Issue 7690, pp. 112-117, (2018) (PubMed).

Zhang, Zhai, Tang, Cheng, Li, Wang, Zhu: "Quantitative proteome-based systematic identification of SIRT7 substrates." in: Proteomics, Vol. 17, Issue 13-14, (2017) (PubMed).

McRae, Booy, Moya-Torres, Ezzati, Stetefeld, McKenna: "Human DDX21 binds and unwinds RNA guanine quadruplexes." in: Nucleic acids research, Vol. 45, Issue 11, pp. 6656-6668, (2017) (PubMed).

Calo, Flynn, Martin, Spitale, Chang, Wysocka: "RNA helicase DDX21 coordinates transcription and ribosomal RNA processing." in: Nature, Vol. 518, Issue 7538, pp. 249-53, (2015) (PubMed).

Moldovan, Moran: "The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition." in: PLoS genetics, Vol. 11, Issue 5, pp. e1005121, (2015) (PubMed).

Miyazawa, Yoshikawa, Magae, Ishikawa, Izumikawa, Terukina, Suzuki, Nakamura-Fujiyama, Miura, Hayano, Komatsu, Isobe, Takahashi: "Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 19, Issue 4, pp. 273-86, (2014) (PubMed).

Synonyms and alternative names related to DDX21

DEAD-box helicase 21 L homeolog (ddx21.L), DExD-box helicase 21 (DDX21), DEAD-box helicase 21 (ddx21), DEAD (Asp-Glu-Ala-Asp) box helicase 21 (ddx21), DExD-box helicase 21 (Ddx21), DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 (Ddx21), AI255159, AL022742, cb960, D10Ertd645e, D10Wsu42e, DDX21, Ddx21a, GUA, GURDB, MGC130693, RH-II/GU, RH-II/GuA, wu:fi30c07, wu:fi34d08

Protein level used designations for DDX21

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
  • RNA helicase II/Gu
  • novel GUCT (NUC152) domain containing DEAD/DEAH box helicase
  • nucleolar RNA helicase 2
  • DEAD box protein 21
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
  • Gu protein
  • RH II/Gu
  • RNA helicase II/Gu alpha
  • gu-alpha
  • nucleolar RNA helicase Gu
  • nucleolar RNA helicase II
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)
  • RH-II/Gualpha
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