DDR2 Products
(Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
Categories
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Featured DDR2 Categories
DDR2 Antibodies
High quality antibodies with extensive validation data.
DDR2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DDR2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DDR2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (4)
Cat. No.
ABIN392069
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, ICC
Validations
- (3)
- (3)
Cat. No.
ABIN969083
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (5)
Cat. No.
ABIN3030741
Quantity
0.4 mL
Datasheet
Datasheet
Recommended DDR2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966390
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955409
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886342
Quantity
96 tests
Datasheet
Datasheet
Recommended DDR2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274461
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274463
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN5854620
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our DDR2 products
: "Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction." in: Theranostics, Vol. 9, Issue 22, pp. 6550-6567, (2019) (PubMed).: "Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib." in: International journal of cancer, Vol. 139, Issue 10, pp. 2359-69, (2016) (PubMed).
: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).
: "NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy." in: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2382-9, (2015) (PubMed).
: "DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 101, (2015) (PubMed).
: "Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation." in: Circulation research, Vol. 115, Issue 7, pp. 625-35, (2014) (PubMed).
: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).
: "Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. ..." in: Cancer discovery, Vol. 1, Issue 1, pp. 78-89, (2012) (PubMed).
: "The discoidin domain receptor DDR2 is a receptor for type X collagen." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, (2006) (PubMed).
: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." in: Hypertension, Vol. 46, Issue 3, pp. 614-21, (2005) (PubMed).
Synonyms and alternative names related to DDR2
discoidin domain receptor tyrosine kinase 2 (DDR2), discoidin domain receptor family, member 2 (Ddr2), discoidin domain receptor tyrosine kinase 2 (Ddr2), discoidin domain receptor family, member 2, like (ddr2l), AW495251, DDR2, ddr2, MIG20a, NTRKR3, Ntrkr3, si:ch211-193c2.1, TKT, TYRO10, tyro10, Tyro10Protein level used designations for DDR2
- CD167 antigen-like family member B
- cell migration-inducing protein 20
- discoidin domain receptor 2
- discoidin domain receptor family, member 2
- discoidin domain-containing receptor 2
- discoidin domain-containing receptor tyrosine kinase 2
- hydroxyaryl-protein kinase
- migration-inducing gene 16 protein
- neurotrophic tyrosine kinase receptor related 3
- neurotrophic tyrosine kinase, receptor-related 3
- receptor protein-tyrosine kinase TKT
- tyrosine-protein kinase TYRO10
- tyrosylprotein kinase
- discoidin domain receptor tyrosine kinase 2
- CD167b antigen
- tyrosine-protein kinase TYRO 10
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