DDC Products
(Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
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The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011].
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DDC Antibodies
High quality antibodies with extensive validation data.
DDC ELISA Kits
Reliable ELISA kits for a wide range of species.
DDC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DDC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (7)
Cat. No.
ABIN1679510
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN651727
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7436294
Quantity
100 μL
Datasheet
Datasheet
Recommended DDC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955437
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962232
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999492
Quantity
96 tests
Datasheet
Datasheet
Recommended DDC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351266
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351264
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667092
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DDC products
: "Optogenetic Activation of A11 Region Increases Motor Activity." in: Frontiers in neural circuits, Vol. 12, pp. 86, (2019) (PubMed).: "Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers." in: Scientific reports, Vol. 8, Issue 1, pp. 7972, (2018) (PubMed).
: "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism." in: Experimental neurology, Vol. 293, pp. 1-12, (2017) (PubMed).
: "Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model." in: Nature biotechnology, Vol. 35, Issue 5, pp. 444-452, (2017) (PubMed).
: "1,25-dyhydroxyvitamin D3 attenuates L-DOPA-induced neurotoxicity in neural stem cells." in: Molecular neurobiology, Vol. 51, Issue 2, pp. 558-70, (2015) (PubMed).
: "Detection of Dopa-positive cells in mouse ovaries in response to ocular exposure to ultraviolet B rays." in: Photodermatology, photoimmunology & photomedicine, (2014) (PubMed).
: "Characterization of A11 neurons projecting to the spinal cord of mice." in: PLoS ONE, Vol. 9, Issue 10, pp. e109636, (2014) (PubMed).
: "SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE." in: Molecular therapy. Methods & clinical development, Vol. 3, (2014) (PubMed).
: "Aromatic l-amino acid decarboxylase expression profiling and isoform detection in the developing porcine brain." in: Brain research, Vol. 1308, pp. 1-13, (2009) (PubMed).
: "Attention-deficit hyperactivity disorder (ADHD)." in: Journal of child neurology, Vol. 19, Issue 10, pp. 798-814, (2004) (PubMed).
Synonyms and alternative names related to DDC
dopa decarboxylase (DDC), dopa decarboxylase (ddc), dopa decarboxylase (Ddc), Dopa-decarboxylase (Dvir\Ddc), dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), Dopa decarboxylase (Ddc), dopa decarboxylase L homeolog (ddc.L), 5-HT, AADC, Aadc, CG10697, Ddc, DDC, ddc, DdcDm, DdcDv, Dmel\\CG10697, Dvir\\GJ17995, dvir_GLEANR_2561, fDDC, GJ17995, l(2)37Bl, l(2)37Ch, l(2)k02104, wu:fa56d05, wu:fd59h03, wu:fk20h01, zgc:65801, zgc:76929Protein level used designations for DDC
- aromatic-L-amino-acid decarboxylase
- L-aromatic dopa decarboxylase
- aromatic-L-amino acid decarboxylase
- aromatic amino acid decarboxylase
- Ddc-PA
- Dvir\\Ddc-PA
- Dvir\\GJ17995-PA
- GJ17995-PA
- L-Dopa decarboxylase
- AADC
- aromatic L-amino acid decarboxylase
- 3,4-Dihydroxyphenylalanine decarboxylase
- CG10697-PB
- CG10697-PC
- CG10697-PD
- Ddc-PB
- Ddc-PC
- Ddc-PD
- dopa decarboxylase
- dopa-decarboxylase
- dopadecarboxylase
- dopamine decarboxylase
- transcription unit No. 3
- dopa decarboxylase (aromatic L-amino acid decarboxylase)
- Aromatic-L-amino-acid decarboxylase
- aromatic-L-amino-acid decarboxylase-like
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