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DDC Products

(Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

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The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011].

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Featured DDC Categories

DDC Antibodies

High quality antibodies with extensive validation data.

DDC ELISA Kits

Reliable ELISA kits for a wide range of species.

DDC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DDC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (7)
Cat. No. ABIN1679510
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, FACS, IHC (p)
Validations
  • (5)
Cat. No. ABIN651727
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7436294
Quantity 100 μL
Datasheet Datasheet

Recommended DDC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955437
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962232
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6999492
Quantity 96 tests
Datasheet Datasheet

Recommended DDC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351266
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351264
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN667092
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DDC products

Koblinger, Jean-Xavier, Sharma, Füzesi, Young, Eaton, Kwok, Bains, Whelan: "Optogenetic Activation of A11 Region Increases Motor Activity." in: Frontiers in neural circuits, Vol. 12, pp. 86, (2019) (PubMed).

Sharma, Kim, Mayr, Elliott, Whelan: "Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers." in: Scientific reports, Vol. 8, Issue 1, pp. 7972, (2018) (PubMed).

Shimohata, Ishihara, Hattori, Miyamoto, Morishita, Ornthanalai, Raveau, Ebrahim, Amano, Yamada, Sago, Akiba, Mataga, Murphy, Miyakawa, Yamakawa: "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism." in: Experimental neurology, Vol. 293, pp. 1-12, (2017) (PubMed).

Rivetti di Val Cervo, Romanov, Spigolon, Masini, Martín-Montañez, Toledo, La Manno, Feyder, Pifl, Ng, Sánchez, Linnarsson, Wernig, Harkany, Fisone, Arenas: "Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model." in: Nature biotechnology, Vol. 35, Issue 5, pp. 444-452, (2017) (PubMed).

Jang, Park, Lee, Lee, Kim, Koh: "1,25-dyhydroxyvitamin D3 attenuates L-DOPA-induced neurotoxicity in neural stem cells." in: Molecular neurobiology, Vol. 51, Issue 2, pp. 558-70, (2015) (PubMed).

Hiramoto, Yamate, Kawanishi: "Detection of Dopa-positive cells in mouse ovaries in response to ocular exposure to ultraviolet B rays." in: Photodermatology, photoimmunology & photomedicine, (2014) (PubMed).

Koblinger, Füzesi, Ejdrygiewicz, Krajacic, Bains, Whelan: "Characterization of A11 neurons projecting to the spinal cord of mice." in: PLoS ONE, Vol. 9, Issue 10, pp. e109636, (2014) (PubMed).

San Sebastian, Kells, Bringas, Samaranch, Hadaczek, Ciesielska, Macayan, Pivirotto, Forsayeth, Osborne, Wright, Green, Heller, Bankiewicz: "SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE." in: Molecular therapy. Methods & clinical development, Vol. 3, (2014) (PubMed).

Blechingberg, Holm, Johansen, Børglum, Nielsen: "Aromatic l-amino acid decarboxylase expression profiling and isoform detection in the developing porcine brain." in: Brain research, Vol. 1308, pp. 1-13, (2009) (PubMed).

Voeller: "Attention-deficit hyperactivity disorder (ADHD)." in: Journal of child neurology, Vol. 19, Issue 10, pp. 798-814, (2004) (PubMed).

Synonyms and alternative names related to DDC

dopa decarboxylase (DDC), dopa decarboxylase (ddc), dopa decarboxylase (Ddc), Dopa-decarboxylase (Dvir\Ddc), dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), Dopa decarboxylase (Ddc), dopa decarboxylase L homeolog (ddc.L), 5-HT, AADC, Aadc, CG10697, Ddc, DDC, ddc, DdcDm, DdcDv, Dmel\\CG10697, Dvir\\GJ17995, dvir_GLEANR_2561, fDDC, GJ17995, l(2)37Bl, l(2)37Ch, l(2)k02104, wu:fa56d05, wu:fd59h03, wu:fk20h01, zgc:65801, zgc:76929

Protein level used designations for DDC

  • aromatic-L-amino-acid decarboxylase
  • L-aromatic dopa decarboxylase
  • aromatic-L-amino acid decarboxylase
  • aromatic amino acid decarboxylase
  • Ddc-PA
  • Dvir\\Ddc-PA
  • Dvir\\GJ17995-PA
  • GJ17995-PA
  • L-Dopa decarboxylase
  • AADC
  • aromatic L-amino acid decarboxylase
  • 3,4-Dihydroxyphenylalanine decarboxylase
  • CG10697-PB
  • CG10697-PC
  • CG10697-PD
  • Ddc-PB
  • Ddc-PC
  • Ddc-PD
  • dopa decarboxylase
  • dopa-decarboxylase
  • dopadecarboxylase
  • dopamine decarboxylase
  • transcription unit No. 3
  • dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Aromatic-L-amino-acid decarboxylase
  • aromatic-L-amino-acid decarboxylase-like
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