DDB2 Products
(Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
Categories
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008].
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Featured DDB2 Categories
DDB2 Antibodies
High quality antibodies with extensive validation data.
DDB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DDB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DDB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN3022632
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7009799
Quantity
60 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN747803
Quantity
100 μL
Datasheet
Datasheet
Recommended DDB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1129989
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1129990
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1129987
Quantity
96 tests
Datasheet
Datasheet
Recommended DDB2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1351259
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351262
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351260
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our DDB2 products
: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).: "Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1658-63, (2013) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
: "Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC." in: Journal of cell science, Vol. 120, Issue Pt 15, pp. 2706-16, (2007) (PubMed).
: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).
: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).
Synonyms and alternative names related to DDB2
damage specific DNA binding protein 2 (DDB2), damage-specific DNA binding protein 2 (ddb2), damage specific DNA binding protein 2 (Ddb2), 2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2Protein level used designations for DDB2
- damage-specific DNA binding protein 2 (48kD)
- damage-specific DNA binding protein 2, 48kDa
- DNA damage-binding protein 2
- Damage-specific DNA-binding protein 2
- DNA damage-binding protein 2-like
- damage-specific DNA-binding protein 2
- DDB p48 subunit
- UV-DDB 2
- UV-damaged DNA-binding protein 2
- xeroderma pigmentosum group E protein
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