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DDB2 Products

(Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008].

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Featured DDB2 Categories

DDB2 Antibodies

High quality antibodies with extensive validation data.

DDB2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DDB2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DDB2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (3)
Cat. No. ABIN3022632
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF
Validations
  • (3)
Cat. No. ABIN7009799
Quantity 60 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN747803
Quantity 100 μL
Datasheet Datasheet

Recommended DDB2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1129989
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1129990
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1129987
Quantity 96 tests
Datasheet Datasheet

Recommended DDB2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1351259
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351262
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351260
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DDB2 products

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Robu, Shah, Petitclerc, BrindAmour, Kandan-Kulangara, Shah: "Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1658-63, (2013) (PubMed).

Abbas, Sivaprasad, Terai, Amador, Pagano, Dutta: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).

Luijsterburg, Goedhart, Moser, Kool, Geverts, Houtsmuller, Mullenders, Vermeulen, van Driel: "Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC." in: Journal of cell science, Vol. 120, Issue Pt 15, pp. 2706-16, (2007) (PubMed).

Shiyanov, Nag, Raychaudhuri: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).

Shiyanov, Hayes, Donepudi, Nichols, Linn, Slagle, Raychaudhuri: "The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4935-43, (1999) (PubMed).

Synonyms and alternative names related to DDB2

damage specific DNA binding protein 2 (DDB2), damage-specific DNA binding protein 2 (ddb2), damage specific DNA binding protein 2 (Ddb2), 2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2

Protein level used designations for DDB2

  • damage-specific DNA binding protein 2 (48kD)
  • damage-specific DNA binding protein 2, 48kDa
  • DNA damage-binding protein 2
  • Damage-specific DNA-binding protein 2
  • DNA damage-binding protein 2-like
  • damage-specific DNA-binding protein 2
  • DDB p48 subunit
  • UV-DDB 2
  • UV-damaged DNA-binding protein 2
  • xeroderma pigmentosum group E protein
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