DcR1 Products
(Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
Categories
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008].
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Featured DcR1 Categories
DcR1 Antibodies
High quality antibodies with extensive validation data.
DcR1 ELISA Kits
Reliable ELISA kits for a wide range of species.
DcR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DcR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN6265636
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (3)
Cat. No.
ABIN301991
Quantity
0.1 mg
Datasheet
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Reactivity
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FACS
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- (2)
Cat. No.
ABIN6579816
Quantity
0.1 mg
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Recommended DcR1 ELISA Kits
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Reactivity
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Cat. No.
ABIN6960280
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96 tests
Datasheet
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Reactivity
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Cat. No.
ABIN5510573
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Recommended DcR1 Proteins
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Reactivity
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Cat. No.
ABIN7275773
Quantity
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Datasheet
Datasheet
Reactivity
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Source
Wheat germ
Validations
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Cat. No.
ABIN1323146
Quantity
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Datasheet
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Reactivity
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Source
Human Cells
Validations
Cat. No.
ABIN7319098
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Datasheet
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Latest Publications for our DcR1 products
: "Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells." in: PLoS ONE, Vol. 14, Issue 4, pp. e0214847, (2019) (PubMed).: "Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells." in: BMC cancer, Vol. 19, Issue 1, pp. 496, (2019) (PubMed).
: "TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells." in: Frontiers in immunology, Vol. 10, pp. 2044, (2019) (PubMed).
: "Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells." in: Cell death & disease, Vol. 8, Issue 8, pp. e3025, (2018) (PubMed).
: "TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis." in: Scientific reports, Vol. 7, Issue 1, pp. 5514, (2017) (PubMed).
: "Targeting Apoptotic Activity Against Prostate Cancer Stem Cells." in: International journal of molecular sciences, Vol. 18, Issue 8, (2017) (PubMed).
: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2." in: Molecular cell, Vol. 65, Issue 4, pp. 730-742.e5, (2017) (PubMed).
: "Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma." in: Stem cells translational medicine, Vol. 3, Issue 2, pp. 172-82, (2014) (PubMed).
: "Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes." in: The Journal of biological chemistry, Vol. 289, Issue 23, pp. 16576-87, (2014) (PubMed).
: "TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells." in: Anticancer research, Vol. 34, Issue 2, pp. 729-34, (2014) (PubMed).
Synonyms and alternative names related to DcR1
TNF receptor superfamily member 10c (TNFRSF10C), CD263, DCR1, DCR1-TNFR, LIT, TNFRSF10C, TRAIL-R3, TRAILR3, TRIDProtein level used designations for DcR1
- TNF-related apoptosis-inducing ligand receptor 3
- antagonist decoy receptor for TRAIL/Apo-2L
- cytotoxic TRAIL receptor-3
- decoy TRAIL receptor without death domain
- decoy receptor 1
- lymphocyte inhibitor of TRAIL
- tumor necrosis factor receptor superfamily member 10C
- tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
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