DCLK2 Products
(Doublecortin-Like Kinase 2 (DCLK2))
Categories
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].
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Featured DCLK2 Categories
DCLK2 Antibodies
High quality antibodies with extensive validation data.
DCLK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DCLK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6258107
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
- (1)
Cat. No.
ABIN1881253
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC
Validations
- (2)
Cat. No.
ABIN2856229
Quantity
100 μL
Datasheet
Datasheet
Recommended DCLK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648188
Quantity
96 tests
Datasheet
Datasheet
Recommended DCLK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508892
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7421590
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7423801
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DCLK2 products
: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).
: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." in: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
Synonyms and alternative names related to DCLK2
doublecortin like kinase 2 (DCLK2), doublecortin-like kinase 2 (Dclk2), doublecortin-like kinase 2a (dclk2a), 6330415M09Rik, AU044875, cb572, CL2, CLICK-II, Click-II, CLICK2, CLIK2, DCAMKL2, Dcamkl2, DCDC3, DCDC3B, DCK2, Dck2, dclk, DCLK2, RGD1308384, sb:cb572, si:dkey-180n16.1Protein level used designations for DCLK2
- CaMK-like CREB regulatory kinase 2
- doublecortin and CaM kinase-like 2
- doublecortin domain-containing protein 3B
- doublecortin-like and CAM kinase-like 2
- serine/threonine-protein kinase DCLK2
- caMK-like CREB regulatory kinase 2
- doublecortin-like kinase 2
- zDCLK
- doublecortin kinase 2
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