DCC Products
(Deleted in Colorectal Carcinoma (DCC))
Categories
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].
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Featured DCC Categories
DCC Antibodies
High quality antibodies with extensive validation data.
DCC ELISA Kits
Reliable ELISA kits for a wide range of species.
DCC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DCC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (4)
Cat. No.
ABIN2782671
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257126
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN656268
Quantity
400 μL
Datasheet
Datasheet
Recommended DCC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966310
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730147
Quantity
96 tests
Datasheet
Datasheet
Recommended DCC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122626
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7013516
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7013754
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DCC products
: "Progesterone down-regulates SLIT/ROBO expression in mouse corpus luteum." in: Acta histochemica, Vol. 119, Issue 7, pp. 740-746, (2017) (PubMed).: "Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain." in: The Journal of comparative neurology, Vol. 520, Issue 16, pp. 3650-72, (2012) (PubMed).
: "The DCC protein and prognosis in colorectal cancer." in: The New England journal of medicine, Vol. 335, Issue 23, pp. 1727-32, (1996) (PubMed).
: "Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues." in: Cancer research, Vol. 54, Issue 16, pp. 4493-501, (1994) (PubMed).
: "Identification of a chromosome 18q gene that is altered in colorectal cancers." in: Science (New York, N.Y.), Vol. 247, Issue 4938, pp. 49-56, (1990) (PubMed).
: "Genetic alterations during colorectal-tumor development." in: The New England journal of medicine, Vol. 319, Issue 9, pp. 525-32, (1988) (PubMed).
: "Clonal analysis of human colorectal tumors." in: Science (New York, N.Y.), Vol. 238, Issue 4824, pp. 193-7, (1987) (PubMed).
Synonyms and alternative names related to DCC
DCC netrin 1 receptor (DCC), DCC netrin 1 receptor (dcc), deleted in colorectal carcinoma (Dcc), deleted in colorectal carcinoma (dcc), DCC netrin 1 receptor (Dcc), netrin receptor DCC (LOC100712666), C030036D22Rik, CRC18, CRCR1, DCC, Dcc, dcca-A, IGDCC1, Igdcc1, MRMV1, xdcc, XDCCa, zdccProtein level used designations for DCC
- colorectal cancer suppressor
- colorectal tumor suppressor
- deleted in colorectal cancer protein
- immunoglobulin superfamily DCC subclass member 1
- immunoglobulin superfamily, DCC subclass, member 1
- netrin receptor DCC
- tumor suppressor protein DCC
- deleted in colorectal carcinoma
- deleted in colorectal cancer
- deleted in colorectal cancer tumor suppressor
- netrin receptor DCC-like
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