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DAXX Products

(Death-Domain Associated Protein (DAXX))

Categories

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].

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Featured DAXX Categories

DAXX Antibodies

High quality antibodies with extensive validation data.

DAXX ELISA Kits

Reliable ELISA kits for a wide range of species.

DAXX Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DAXX Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (5)
Cat. No. ABIN514879
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ICC
Validations
  • (1)
  • (3)
Cat. No. ABIN94302
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS, ICC
Validations
  • (4)
Cat. No. ABIN969493
Quantity 100 μL
Datasheet Datasheet

Recommended DAXX ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966275
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966276
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380165
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended DAXX Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351120
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351122
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424761
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DAXX products

Yang, Hu, Chen, Zhu, Li, Lu, Li, Dong: "Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats." in: Neuroscience letters, Vol. 651, pp. 207-215, (2017) (PubMed).

Pipinikas, Dibra, Karpathakis, Feber, Novelli, Oukrif, Fusai, Valente, Caplin, Meyer, Teschendorff, Bell, Morris, Salomoni, Luong, Davidson, Beck, Thirlwell: "Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. L13-8, (2015) (PubMed).

Fishbein, Khare, Wubbenhorst, DeSloover, DAndrea, Merrill, Cho, Greenberg, Else, Montone, LiVolsi, Fraker, Daber, Cohen, Nathanson: "Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas." in: Nature communications, Vol. 6, pp. 6140, (2015) (PubMed).

Napier, Huschtscha, Harvey, Bower, Noble, Hendrickson, Reddel: "ATRX represses alternative lengthening of telomeres." in: Oncotarget, Vol. 6, Issue 18, pp. 16543-58, (2015) (PubMed).

Yoshida, Ogawa, Yoshida, Maeshima, Kanai, Kinoshita, Hiraoka, Sekine: "TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast." in: British journal of cancer, Vol. 113, Issue 8, pp. 1244-8, (2015) (PubMed).

Weisbrod, Zhang, Jain, Barak, Quezado, Kebebew: "Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors." in: Hormones & cancer, Vol. 4, Issue 3, pp. 165-75, (2013) (PubMed).

Stepp, Meyers, McBride: "Sp100 provides intrinsic immunity against human papillomavirus infection." in: mBio, Vol. 4, Issue 6, pp. e00845-13, (2013) (PubMed).

Schwartzentruber, Korshunov, Liu, Jones, Pfaff, Jacob, Sturm, Fontebasso, Quang, Tönjes, Hovestadt, Albrecht, Kool, Nantel, Konermann, Lindroth, Jäger, Rausch, Ryzhova, Korbel, Hielscher, Hauser et al.: "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. ..." in: Nature, Vol. 482, Issue 7384, pp. 226-31, (2012) (PubMed).

de Wilde, Heaphy, Maitra, Meeker, Edil, Wolfgang, Ellison, Schulick, Molenaar, Valk, Vriens, Borel Rinkes, Offerhaus, Hruban, Matsukuma: "Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 25, Issue 7, pp. 1033-9, (2012) (PubMed).

Heaphy, de Wilde, Jiao, Klein, Edil, Shi, Bettegowda, Rodriguez, Eberhart, Hebbar, Offerhaus, McLendon, Rasheed, He, Yan, Bigner, Oba-Shinjo, Marie, Riggins, Kinzler, Vogelstein, Hruban, Maitra et al.: "Altered telomeres in tumors with ATRX and DAXX mutations. ..." in: Science (New York, N.Y.), Vol. 333, Issue 6041, pp. 425, (2011) (PubMed).

Synonyms and alternative names related to DAXX

death domain associated protein (DAXX), Fas death domain-associated protein (Daxx), 28S ribosomal protein S29, mitochondrial (LOC100226911), death-domain associated protein (Daxx), death domain associated protein (Daxx), death-associated protein 6 L homeolog (daxx.L), death-domain associated protein (daxx), BING2, DAP6, daxx, EAP1, LOC100226911, si:dz179b20.7, wu:fd15c03

Protein level used designations for DAXX

  • CENP-C binding protein
  • ETS1-associated protein 1
  • Fas-binding protein
  • death domain-associated protein 6
  • death-associated protein 6
  • fas death domain-associated protein
  • death-domain associated protein
  • death associated protein 3
  • Fas death domain-associated protein
  • LOW QUALITY PROTEIN: death domain-associated protein 6
  • death-associated protein 6 L homeolog
  • fas-binding
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