DAB2 Products
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
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This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Featured DAB2 Categories
DAB2 Antibodies
High quality antibodies with extensive validation data.
DAB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
DAB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DAB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN514859
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652936
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN760961
Quantity
100 μL
Datasheet
Datasheet
Recommended DAB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966388
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882557
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1129853
Quantity
96 tests
Datasheet
Datasheet
Recommended DAB2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122677
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351061
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351065
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our DAB2 products
: "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy." in: Nature cell biology, Vol. 18, Issue 8, pp. 851-63, (2016) (PubMed).: "The histone demethylase Kdm3a is essential to progression through differentiation." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7219-32, (2012) (PubMed).
: "Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15087-99, (2012) (PubMed).
: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).
: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." in: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).
: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).
: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).
: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." in: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).
: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." in: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).
: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." in: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).
Synonyms and alternative names related to DAB2
DAB2, clathrin adaptor protein (DAB2), disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2), Dab, mitogen-responsive phosphoprotein, homolog 2 (dab2), DAB2, clathrin adaptor protein (Dab2), disabled 2, mitogen-responsive phosphoprotein (Dab2), 5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, DOC-2, Doc-2, DOC2, Doc2, p96Protein level used designations for DAB2
- disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- disabled homolog 2
- disabled homolog 2, mitogen-responsive phosphoprotein
- disabled homolog 2-like
- differentially-expressed protein 2
- mitogen-responsive phosphoprotein
- C9
- DOC-2 p82 isoform
- disabled homolog 2 mitogen-responsive phosphoprotein
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