CYP3A4 Products
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
Categories
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured CYP3A4 Categories
CYP3A4 Antibodies
High quality antibodies with extensive validation data.
CYP3A4 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP3A4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP3A4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS, ICC
Validations
- (2)
- (7)
Cat. No.
ABIN969512
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, FACS, IF (p), IHC (p), ICC, IF (cc), IHC (fro)
Validations
- (1)
- (4)
Cat. No.
ABIN733793
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (4)
Cat. No.
ABIN514838
Quantity
50 μg
Datasheet
Datasheet
Recommended CYP3A4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955259
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966251
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955258
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP3A4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122583
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350990
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350988
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CYP3A4 products
: "PAMAM dendrimer grafted cellulose paper scaffolds as a novel in vitro 3D liver model for drug screening applications." in: Colloids and surfaces. B, Biointerfaces, Vol. 172, pp. 346-354, (2019) (PubMed).: "Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver." in: International journal of molecular sciences, Vol. 20, Issue 18, (2019) (PubMed).
: "Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes." in: Toxicology, Vol. 404-405, pp. 76-85, (2019) (PubMed).
: "Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine." in: PLoS ONE, Vol. 13, Issue 3, pp. e0194979, (2018) (PubMed).
: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).
: "Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 11, pp. 951-961, (2017) (PubMed).
: "Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance." in: Biochemical pharmacology, Vol. 98, Issue 1, pp. 224-30, (2015) (PubMed).
: "Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice." in: Life sciences, Vol. 95, Issue 1, pp. 1-8, (2014) (PubMed).
: "Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system." in: Skin pharmacology and physiology, Vol. 27, Issue 5, pp. 263-75, (2014) (PubMed).
: "Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance." in: Clinical pharmacology and therapeutics, Vol. 95, Issue 4, pp. 416-22, (2014) (PubMed).
Synonyms and alternative names related to CYP3A4
cytochrome P450 family 3 subfamily A member 4 (CYP3A4), cytochrome P450 family 3 subfamily A member 43 (CYP3A43), cytochrome P450 3A4 (PTRG_01782), cytochrome P450 3A4 (PTRG_06060), cytochrome P450 family 3 subfamily A member 4 (cyp3a4), cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4), cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4), cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1Protein level used designations for CYP3A4
- 1,8-cineole 2-exo-monooxygenase
- P450-III, steroid inducible
- albendazole monooxygenase
- albendazole sulfoxidase
- cytochrome P450 3A3
- cytochrome P450 3A4
- cytochrome P450 HLp
- cytochrome P450 NF-25
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- cytochrome P450-PCN1
- glucocorticoid-inducible P450
- nifedipine oxidase
- quinine 3-monooxygenase
- taurochenodeoxycholate 6-alpha-hydroxylase
- cytochrome P450 3A43
- cytochrome P450, subfamily IIIA, polypeptide 43
- cytochrome P450, family 3, subfamily A, polypeptide 4
- cytochrome P450 3A80
- Cytochrome P450 CM3A-10
- cytochrome P450 3A21
- cytochrome P450 CYP3A12
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