CYP2C8 Products
(Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))
Categories
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
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Featured CYP2C8 Categories
CYP2C8 Antibodies
High quality antibodies with extensive validation data.
CYP2C8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP2C8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN6258063
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN514832
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN947772
Quantity
50 μg
Datasheet
Datasheet
Recommended CYP2C8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6214689
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP2C8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122581
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350971
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3078039
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CYP2C8 products
: "Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8." in: Frontiers in pharmacology, Vol. 6, pp. 261, (2015) (PubMed).: "Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity." in: The pharmacogenomics journal, Vol. 11, Issue 2, pp. 121-9, (2011) (PubMed).
: "Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)." in: American journal of physiology. Renal physiology, Vol. 301, Issue 3, pp. F672-81, (2011) (PubMed).
: "Cytochromes P450: a success story." in: Genome biology, Vol. 1, Issue 6, pp. REVIEWS3003, (2001) (PubMed).
Synonyms and alternative names related to CYP2C8
cytochrome P450 family 2 subfamily C member 8 (CYP2C8), Cytochrome P450 2C8 (CTN_0597), cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), cytochrome P450 family 2 subfamily C member 8 S homeolog (cyp2c8.1.S), cytochrome P450 family 2 subfamily C member 8 (cyp2c8.1), CPC8, cpc8, cyp2c8, CYP2C74, CYPIIC8, cypiic8, MP-12/MP-20, mp-12/mp-20Protein level used designations for CYP2C8
- P450 form 1
- cytochrome P450 2C8
- cytochrome P450 IIC2
- cytochrome P450 MP-12
- cytochrome P450 MP-20
- cytochrome P450 form 1
- cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- s-mephenytoin 4-hydroxylase
- xenobiotic monooxygenase
- Cytochrome P450 2C8
- cytochrome P450 CYP2C74
- cytochrome P450, family 2, subfamily C, polypeptide 8
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