CYP2B6 Products
(Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))
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This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described\; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008].
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Featured CYP2B6 Categories
CYP2B6 Antibodies
High quality antibodies with extensive validation data.
CYP2B6 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP2B6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP2B6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN1679474
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (2)
- (3)
Cat. No.
ABIN655056
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7258000
Quantity
200 μL
Datasheet
Datasheet
Recommended CYP2B6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955243
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966236
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955242
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP2B6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350963
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407754
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3078137
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CYP2B6 products
: "Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis." in: Endocrinology, Vol. 159, Issue 6, pp. 2435-2446, (2019) (PubMed).: "Exposure of pregnant mice to triclosan impairs placental development and nutrient transport." in: Scientific reports, Vol. 7, pp. 44803, (2017) (PubMed).
: "Characterization of feline cytochrome P450 2B6." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 2, pp. 93-102, (2017) (PubMed).
: "Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer." in: Archives of pharmacal research, Vol. 38, Issue 5, pp. 725-33, (2015) (PubMed).
: "Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120055, (2015) (PubMed).
: "Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression." in: Steroids, Vol. 80, pp. 1-6, (2014) (PubMed).
: "The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients." in: Medicine, Vol. 93, Issue 28, pp. e255, (2014) (PubMed).
: "Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA." in: Scientific reports, Vol. 2, pp. 639, (2012) (PubMed).
: "Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 1, pp. 54-63, (2011) (PubMed).
Synonyms and alternative names related to CYP2B6
cytochrome P450 family 2 subfamily B member 6 (CYP2B6), cytochrome P450 family 4 subfamily F member 3 (CYP4F3), cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6), cytochrome P450 family 2 subfamily B member 6 L homeolog (cyp2b6.L), cytochrome P450 2B11 (CYP2B6), cytochrome P450, family 21, subfamily a, polypeptide 1 (Cyp21a1), cytochrome P450 subfamily 2B (CYP2B6), cytochrome P450 2B11-like (LOC100068603), 21-OH, 21OH, 21OHA, 21OHB, CPB6, CPF3, CYP2B, CYP2B6, CYP2B7, CYP2B7P, CYP2B11, CYP2B30, CYP4F, Cyp21, Cyp21-ps1, Cyp21a2-ps, Cyp21a2ps, Cyp21B, CYP21OH-A, CYPIIB6, CYPIIB11, EFVM, IIB1, LTB4H, Oh21-1, Oh21-2, P450Protein level used designations for CYP2B6
- 1,4-cineole 2-exo-monooxygenase
- cytochrome P450 2B6
- cytochrome P450 IIB1
- cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
- CYPIVF3
- cytochrome P-450
- cytochrome P450 4F3
- cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase)
- cytochrome P450-LTB-omega
- leukotriene B4 omega hydroxylase
- leukotriene-B(4) 20-monooxygenase 2
- leukotriene-B(4) omega-hydroxylase 2
- leukotriene-B4 20-monooxygenase
- cytochrome P450 CYP2B30
- cytochrome P450, family 2, subfamily B, polypeptide 6
- cytochrome P450 PBD-2
- cytochrome P450, family 2, subfamily B, polypeptide 11
- 21-OHase
- 21-hydroxylase
- cytochrome P-450c21
- cytochrome P450 21
- cytochrome P450 XXI
- cytochrome P450 hydroxylase A
- cytochrome P450, 21, pseudogene
- cytochrome P450, 21, steroid 21 hydroxylase
- cytochrome P450, family 21, subfamily a, polypeptide 2, pseudogene
- cytochrome P450-C21
- steroid 21 hydroxylase
- steroid 21-hydroxylase
- cytochrome P450 subfamily 2B
- Cytochrome P450 2B6
- LOW QUALITY PROTEIN: cytochrome P450 2B11-like
- cytochrome P450 2B11-like
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