CYP2A6 Products
(Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
Categories
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3\; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008].
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Featured CYP2A6 Categories
CYP2A6 Antibodies
High quality antibodies with extensive validation data.
CYP2A6 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP2A6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP2A6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, IHC, FACS, IHC (p)
Validations
- (10)
Cat. No.
ABIN1497724
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN1497722
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN1497723
Quantity
100 μL
Datasheet
Datasheet
Recommended CYP2A6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966235
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP2A6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350959
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3078038
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2712760
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our CYP2A6 products
: "Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes." in: Scientific reports, Vol. 7, pp. 40716, (2018) (PubMed).: "Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes." in: Pharmacogenomics, Vol. 12, Issue 4, pp. 481-92, (2011) (PubMed).
: "Inhibitory effects of neurotransmitters and steroids on human CYP2A6." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 35, Issue 4, pp. 508-14, (2007) (PubMed).
: "The role of CYP2A6 in the emergence of nicotine dependence in adolescents." in: Pediatrics, Vol. 119, Issue 1, pp. e264-74, (2007) (PubMed).
: "Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence." in: Pharmacogenetics and genomics, Vol. 15, Issue 2, pp. 115-25, (2005) (PubMed).
: "Cytochromes P450: a success story." in: Genome biology, Vol. 1, Issue 6, pp. REVIEWS3003, (2001) (PubMed).
: "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes." in: Biochemistry, Vol. 29, Issue 5, pp. 1322-9, (1990) (PubMed).
: "Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity." in: Nucleic acids research, Vol. 17, Issue 8, pp. 2907-17, (1989) (PubMed).
: "cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)." in: Nucleic acids research, Vol. 17, Issue 12, pp. 4888, (1989) (PubMed).
Synonyms and alternative names related to CYP2A6
cytochrome P450 family 2 subfamily A member 6 (CYP2A6), cytochrome P450 2A6 (CYP2A6), cytochrome P450 family 2 subfamily A member 6 L homeolog (cyp2a6.L), CPA6, CYP2A, CYP2A3, cyp2a6, CYPIIA6, P450C2A, P450PBProtein level used designations for CYP2A6
- 1,4-cineole 2-exo-monooxygenase
- coumarin 7-hydroxylase
- cytochrome P450 2A6
- cytochrome P450 IIA3
- cytochrome P450(I)
- cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
- flavoprotein-linked monooxygenase
- xenobiotic monooxygenase
- cytochrome P450 2A13
- cytochrome P-450
- cytochrome P450 family 2 subfamily A member 6 L homeolog
- cytochrome P450, family 2, subfamily A, polypeptide 6
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