CYP1A2 Products
(Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))
Categories
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008].
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Featured CYP1A2 Categories
CYP1A2 Antibodies
High quality antibodies with extensive validation data.
CYP1A2 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP1A2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP1A2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, FACS, IHC (p)
Validations
- (6)
Cat. No.
ABIN1497712
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p)
Validations
- (2)
- (3)
Cat. No.
ABIN655272
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN947768
Quantity
100 μg
Datasheet
Datasheet
Recommended CYP1A2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955229
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955230
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6955231
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP1A2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1350938
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350937
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397363
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CYP1A2 products
: "Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes." in: Toxicology, Vol. 404-405, pp. 76-85, (2019) (PubMed).: "Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 160, Issue 1, pp. 173-179, (2018) (PubMed).
: "Reduction of Aflatoxin B1 Toxicity by Lactobacillus plantarum C88: A Potential Probiotic Strain Isolated from Chinese Traditional Fermented Food "Tofu"." in: PLoS ONE, Vol. 12, Issue 1, pp. e0170109, (2017) (PubMed).
: "Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 11, pp. 951-961, (2017) (PubMed).
: "Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats." in: Molecular nutrition & food research, Vol. 60, Issue 9, pp. 1956-66, (2016) (PubMed).
: "Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats." in: The Journal of nutrition, Vol. 145, Issue 3, pp. 442-51, (2015) (PubMed).
: "Differential expression of HO-1 and CYP1A2 during up-regulation of ERK in stressed fish hepatocytes." in: Environmental monitoring and assessment, Vol. 187, Issue 1, pp. 4147, (2014) (PubMed).
: "Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 107-15, (2014) (PubMed).
: "Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 42, Issue 12, pp. 1982-90, (2014) (PubMed).
: "Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. ..." in: Human molecular genetics, Vol. 20, Issue 10, pp. 2071-7, (2011) (PubMed).
Synonyms and alternative names related to CYP1A2
cytochrome P450 family 1 subfamily A member 2 (CYP1A2), cytochrome P450 1A2 (CYP1A2), cytochrome P450 LM4 (LOC100328937), cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2), cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2), cytochrome P450 1A2 (VDBG_06455), cytochrome P450 1A2-like (LOC101825565), cytochrome P450 1A2 (LOC102130662), CP12, CP450, CYP-IA2, Cyp1a1, CYP1A2, CYP1A5, CYPD45, CYPIA2, P-450d, P3-450, P450(PA), P450-3, P450-PM4, RATCYPD45Protein level used designations for CYP1A2
- CYPIA2
- P450 form 4
- aryl hydrocarbon hydroxylase
- cytochrome P(3)450
- cytochrome P450 1A2
- cytochrome P450 4
- cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
- cytochrome P450-P3
- dioxin-inducible P3-450
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- xenobiotic monooxygenase
- P450 LM4
- P450 isozyme 4
- cytochrome P450 isozyme 4
- cytochrome P450-PM4
- aromatic compound inducible
- cytochrome P450 family 1 subfamily a polypeptide 1
- cytochrome P450, 1a2, aromatic compound inducible
- cytochrome P450-P2
- Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d)
- P-448
- P450-D
- cytochrome P-448
- cytochrome P-450d
- cytochrome P450, 1a2
- cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d)
- cytochrome P450-D
- CYPIA5
- cytochrome P450 1A5
- cytochrome P450 TCDDAA
- Cytochrome P450-MC4
- Hepatic cytochrome P-450MC1
- cytochrome P-450 form 4
- cytochrome P-450IA2
- pulmonary cytochrome P-450MC1
- Cholesterol 25-hydroxylase
- cholesterol 25-hydroxylase
- cytochrome P-450
- cytochrome P450, family 1, subfamily A, polypeptide 2
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