Cyclin E1 Products
(Cyclin E1 (CCNE1))
Categories
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008].
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Featured Cyclin E1 Categories
Cyclin E1 Antibodies
High quality antibodies with extensive validation data.
Cyclin E1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Cyclin E1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cyclin E1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN7193589
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (5)
Cat. No.
ABIN2682980
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, StM
Validations
- (5)
Cat. No.
ABIN6940994
Quantity
100 μg
Datasheet
Datasheet
Recommended Cyclin E1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975049
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5519251
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN4993358
Quantity
96 tests
Datasheet
Datasheet
Recommended Cyclin E1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348459
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348461
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7320118
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Cyclin E1 products
: "Advanced oxidation protein products induce S-phase arrest of hepatocytes via the ROS-dependent, β-catenin-CDK2-mediated pathway." in: Redox biology, Vol. 14, pp. 338-353, (2018) (PubMed).: "Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway." in: Molecular medicine reports, Vol. 17, Issue 2, pp. 3062-3068, (2018) (PubMed).
: "Potential biomarkers of DNA replication stress in cancer." in: Oncotarget, Vol. 8, Issue 23, pp. 36996-37008, (2018) (PubMed).
: "GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer." in: Oncotarget, Vol. 8, Issue 63, pp. 106608-106624, (2017) (PubMed).
: "Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 33, pp. 21-27, (2017) (PubMed).
: "Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level." in: BMC cell biology, Vol. 16, pp. 25, (2016) (PubMed).
: "Studying the relationship between cell cycle and Alzheimer's disease by gold nanoparticle probes." in: Analytical biochemistry, Vol. 489, pp. 32-7, (2015) (PubMed).
: "Concentration-Dependent Diversifcation Effects of Free Cholesterol Loading on Macrophage Viability and Polarization." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 37, Issue 2, pp. 419-31, (2015) (PubMed).
: "Platelet-rich plasma increases proliferation of tendon cells by modulating Stat3 and p27 to up-regulate expression of cyclins and cyclin-dependent kinases." in: Cell proliferation, Vol. 48, Issue 4, pp. 413-20, (2015) (PubMed).
: "STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7." in: Cancer cell international, Vol. 15, pp. 111, (2015) (PubMed).
Synonyms and alternative names related to Cyclin E1
cyclin E1 (CCNE1), cyclin E1 (ccne1), cyclin E1 (Ccne1), cyclin E1 L homeolog (ccne1.L), cyclin E1 S homeolog (ccne1.S), AW538188, ccne, CCNE, Ccne, CCNE1, cyce, CycE1, cyce2, cycE3, CYCLE, cyclinE, fa18e07, wu:fa18e07Protein level used designations for Cyclin E1
- cyclin E1
- G1/S-specific cyclin-E1
- G1/S-specific cyclin-E1-like
- g1/S-specific cyclin-E1-like
- cyclin Es
- cyclin Et
- cyclin E
- G1/S-specific cyclin-E2
- cyclin-E-1
- G1/S-specific cyclin-E3
- cyclin E3
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